Results 191 to 200 of about 14,157,417 (290)

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source

Maternal Anemia and Pediatric Neurodevelopment in Children from Mothers Exposed to Mixed Heavy Metals in Suriname. [PDF]

J Xenobiot
Gokoel AR, Shankar A, Mokiem SF, Hindori-Mohangoo AD, Lichtveld MY, Wickliffe JK, Zijlmans WCWR.   +6 more
europepmc   +1 more source

Gene Therapy for Amino Acid Decarboxylase Deficiency: Clinical and Imaging Outcomes in a French Cohort

Movement Disorders, EarlyView.
Abstract Background Intracerebral gene therapy is effective for amino acid decarboxylase (AADC) deficiency, but relationships between anatomical putaminal coverage, metabolic dynamics, and clinical recovery remain poorly understood. Objectives Assess safety, long‐term efficacy, and clinical–radiological correlations in a genetically diverse European ...
Clément Dunoyer, Gaëtan Poulen, Marie‐Céline François‐Heude, Eline Chauvet‐Piat, Bérénice Lecardonnel, Emmanuel Roze, Marie‐Ange Nguyen Morel, Domitille Gras, Adeline Quintard, Gaelle Baroux, Pierre Meyer, Philippe Coubes, Christophe Milesi, Julien Baleine, Chrystelle Sola, Vivien Szabo, Bénédicte Delye, Jana Haberlova, Mohamed Osman Eltahir Babiker, Mohammed Al Muqbil, Stéphanie Sanchez, Souad Touati, Nicolas Leboucq, Virginie Kouyoumdjian, Sylvia Sanquer, Denis Mariano‐Goulart, Thomas Roujeau, Agathe Roubertie   +27 more
wiley   +1 more source

[Training and community-based intervention to reduce chronic benzodiazepine use for insomnia and distress in primary care]. [PDF]

Aten Primaria
Illamola Martin L, Núñez Sabaté C, Bonet Monne S, Arroyo Jiménez M.   +3 more
europepmc   +1 more source

Optimizing Research Operations and Resource Utilization in ALS Care: Insights From the Tofersen Antisense Oligonucleotide Expanded Access Protocol

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Tofersen is a gene‐targeted therapy for individuals with superoxide dismutase 1 (SOD1) (+) amyotrophic lateral sclerosis (ALS). Prior to U.S. Food and Drug Administration (FDA) approval, tofersen was made available through expanded access protocol.
Alison Wheeler, Kush Mehta, Danica Sanders, Cathy Chin, Hannah Zivalic, Judith Carey, Alexandra McCaffrey, Pravin Pant, Carl Lewenhaupt, Sarah Luppino, Gabriel Jacobs, Shea Golden, Ryan Gifford, Erica Scirocco, Mackenzie Keegan, Munaf Hatem, Taravat Yazdanian, Sanem P. Uysal, Natalie Susco, Shauna Schwartzman, Karen Branch, Kathryn E. Hall, Joanna Barnas, Jenny Lam, Jennifer Hagar, Carol Ann Hannan, Sabrina Paganoni, James D. Berry, Mark Garret, Jennifer Scalia, Suma Babu   +30 more
wiley   +1 more source

[Hyperuricaemia as a cardiovascular risk factor]. [PDF]

Aten Primaria
Álvarez Lozano B, Deniel-Rosanas J, Ortiz Arissó B, Roura-Poch P.   +3 more
europepmc   +1 more source

Q-factor Controlled MMIC Active Resonator using Bias Circuit and its Application to Band Pass Filter. [PDF]

, 1999
Kwon, Young Se
core  

[Impulse control disorder: patients with pituitary adenomas and dopaminergic agonists]. [PDF]

Rev Med Inst Mex Seguro Soc
Barreras-Ruíz A, Rangel-Sánchez MG, Ávalos-Salgado FA, Espinel-Bermúdez MC, Hernández-González SO.   +4 more
europepmc   +1 more source

Fabrication of Top Electrode Vertical Cavity Front Surface Emitting Laser Diode (FSELD) Using HBT Process [PDF]

, 1990
Kwon, Young Se
core  

One‐Year Functional Satisfaction and Quality of Life Outcomes of Patients With a History of Radiotherapy With Artificial Urinary Sphincters

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims This study assessed how functional satisfaction and quality of life outcomes of the artificial urinary sphincter (AUS) were affected in patients who received radiation for prostate cancer. Methods A secondary analysis was conducted based on the Artificial Urinary Sphincter Clinical Outcomes (AUSCO) study, a prospective multi‐institutional
Vishu Chandrasekhar, Melissa R. Kaufman, Andrew C. Peterson, Erin L. Chaussee, Hadley M. Wood, AUSCO Collaboration Group, Benjamin N. Breyer, Bradley A. Erickson, Niels V. Johnsen, Jeremy Myers, Alex J. Vanni, Ryan Terlecki, Thomas G. Smith III, Daniel Moon Fracs, LeRoy Jones, Joshua A. Broghammer, Gerard Henry, Arthur L. Burnett, Lewis Wen Loong Chan, Brian J. Flynn, Rose Khavari, Sean Elliott   +21 more
wiley   +1 more source