Results 111 to 120 of about 13,240,439 (301)
Landscape Trajectories: sea level rise and future landscapes [PDF]
, 2017 Looking out over a quiet sea lapping the shore on a sunny day, it is almost inconceivable to think that it is inexorably rising. The globe is locked into a future of sea level rise of anywhere between 30 cm and 1 metre by 2100, and possibly much higher ...
Stephenson, Janet
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Treading Water: Tools to Help US Coastal Communities Plan for Sea Level Rise Impacts
Frontiers in Marine Science, 2019 As communities grapple with rising seas and more frequent flooding events, they need improved projections of future rising and flooding over multiple time horizons, to assist in a multitude of planning efforts.
Emily A. Smith +11 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2008 Here we present a set of regional climate scenarios of sea level rise for the northeast Atlantic Ocean. In this study, the latest observations and results obtained with state-of-the-art climate models are combined.
Geert Jan van Oldenborgh +9 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
THE DOUBLE TRADE-OFF BETWEEN ADAPTATION AND MITIGATION FOR SEA LEVEL RISE: AN APPLICATION OF FUND [PDF]
The effects of adaptation and mitigation on the impacts of sea level rise are studied. Without either, the impacts of sea level rise would be substantial, almost wiping out entire nations before 2100; the global effect is much smaller.
Richard S.J. Tol
core
Coastal subsidence and relative sea level rise
Environmental Research Letters, 2014 Subsurface fluid-pressure declines caused by pumping of groundwater or hydrocarbons can lead to aquifer-system compaction and consequent land subsidence.
S E Ingebritsen, D L Galloway
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source