Results 251 to 260 of about 5,134,596 (300)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Assessing the onset of spring water-level rise in snowmelt-dominated rivers of northeastern Russia using machine learning. [PDF]

Sci Rep
Malashin I, Masich I, Nelyub V, Borodulin A, Gantimurov A, Tynchenko V.   +5 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Insolation-forced oceanic changes triggered the Eurasian Ice Sheet collapse and the Last Termination. [PDF]

Nat Commun
Wu D, Li S, Eiríksson J, Guðmundsdóttir ER, Rosenthal Y, Hu N, Fan D, Liu Y, Zhang X.   +8 more
europepmc   +1 more source

Enhanced carbon loss in the Southern Ocean under mitigation scenarios. [PDF]

Sci Adv
Lee H, Kug JS, Shin Y, Lee DG, Goris N, Fröb F, Tjiputra JF, Bourgeois T, Schwinger J.   +8 more
europepmc   +1 more source

Unraveling daily dynamics of supraglacial lakes in response to hydrological pulses and anomalous climate signals. [PDF]

Nat Commun
Song J, Qiu H, Emmer A, Zhang G, Wang N, Liu Y, Yang G, Liang Y.   +7 more
europepmc   +1 more source

Prioritizing Shark, Ray, and Chimaera Conservation in Rapidly Changing Polar Waters. [PDF]

Glob Chang Biol
Bettcher VB, Batlle-Morera A, Kyne PM, Charles R, García-Rodríguez E, Rohner CA, Armstrong AO, O'Leary Amsler M, Chernova NV, Devine BM, Dolgov AV, Donovan MM, Faure J, Finucci B, Fisher JAD, Forbes RAS, Hedges KJ, Hollyman PR, Hussey NE, Jac R, Kulka DW, Orlov AM, Péron C, Schaber M, Ste-Marie E, Weigmann S, Jabado RW.   +26 more
europepmc   +1 more source

A 26-Year Record of Seasonality and Interannual Variability in Marine Mammal Sightings From Northern Marguerite Bay, Antarctica. [PDF]

Ecol Evol
Clarke A, Fisher A, Venables HJ, Allen L, Davies RG.   +4 more
europepmc   +1 more source

Sea ice dynamics solvers in the MITgcm

, 2018
openaire   +1 more source

Denning Phenology Mediates Sea-Ice Loss Impacts on Early Reproductive Success in Polar Bears. [PDF]

Glob Chang Biol
Naciri M, Aars J, Gamelon M, Andersen M, Derocher AE, Wiig Ø, Cubaynes S.   +6 more
europepmc   +1 more source