Results 121 to 130 of about 2,565,243 (371)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Capacity of a set of CMIP6 models to simulate Arctic sea ice drift

Annals of Glaciology
Evaluating CMIP6 model performance helps to improve the prediction of future changes in Arctic sea ice. We analyze the seasonal cycles, distribution, and evolution of sea ice in different regions from 1979 to 2014.
Xinfang Zhang, Jari Haapala, Petteri Uotila   +2 more
doaj   +1 more source

Southern Ocean warming: Increase in basal melting and grounded ice loss [PDF]

, 2013
We apply a global finite element sea ice/ice shelf/ocean model (FESOM) to the Antarctic marginal seas to analyze projections of ice shelf basal melting in a warmer climate.
Determann, Jürgen, Hellmer, Hartmut, Timmermann, Ralph   +2 more
core  

Landfast Ice Controls on Turbulence in Antarctic Coastal Seas [PDF]

, 2021
Mark Inall, J. Alexander Brearley, Sian F. Henley, Alexander Fraser, Sarah E. Reed   +4 more
openalex   +1 more source

Arctic warming interrupts the Transpolar Drift and affects long-range transport of sea ice and ice-rafted matter

Scientific Reports, 2019
Sea ice is an important transport vehicle for gaseous, dissolved and particulate matter in the Arctic Ocean. Due to the recently observed acceleration in sea ice drift, it has been assumed that more matter is advected by the Transpolar Drift from shallow
T. Krumpen, H. J. Belter, A. Boetius, E. Damm, C. Haas, S. Hendricks, M. Nicolaus, E. Nöthig, S. Paul, I. Peeken, R. Ricker, R. Stein   +11 more
semanticscholar   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Seasonal Arctic Sea Ice Prediction Using a Newly Developed Fully Coupled Regional Model With the Assimilation of Satellite Sea Ice Observations

Journal of Advances in Modeling Earth Systems, 2020
To increase our capability to predict Arctic sea ice and climate, we have developed a coupled atmosphere‐sea ice‐ocean model configured for the pan‐Arctic with sufficient flexibility.
Chao‐Yuan Yang, Jiping Liu, Shiming Xu
doaj   +1 more source

More frequent atmospheric rivers slow the seasonal recovery of Arctic sea ice

, 2023
Pengfei Zhang, Gang Chen, Mingfang Ting, L. Ruby Leung, Bin Guan, Laifang Li   +5 more
openalex   +2 more sources

Variability modes of September Arctic sea ice: drivers and their contributions to sea ice trend and extremes [PDF]

, 2023
Mehdi Pasha Karami, Torben Koenigk, Bruno Tremblay   +2 more
openalex   +1 more source

The Role of Atlantic Heat Transport in Future Arctic Winter Sea Ice Loss

Journal of Climate, 2019
During recent decades Arctic sea ice variability and retreat during winter have largely been a result of variable ocean heat transport (OHT). Here we use the Community Earth System Model (CESM) large ensemble simulation to disentangle internally and ...
M. Årthun, T. Eldevik, L. Smedsrud
semanticscholar   +1 more source