Results 91 to 100 of about 38,499 (290)

An ensemble reconstruction of global monthly sea surface temperature and sea ice concentration 1000-1849. [PDF]

Sci Data, 2021
Samakinwa E, Valler V, Hand R, Neukom R, Gómez-Navarro JJ, Kennedy J, Rayner NA, Brönnimann S.   +7 more
europepmc   +1 more source

Strong ocean/sea-ice contrasts observed in satellite-derived ice crystal number concentrations in Arctic boundary-layer clouds [PDF]

, 2022
Iris Papakonstantinou Presvelou, Odran Sourdeval, Johannes Quaas   +2 more
openalex   +1 more source

On sea ice concentration anomaly coherence in the southern Beaufort Sea

Geophysical Research Letters, 2005
The circumpolar flaw lead polynya system is a region of enhanced biological productivity and for significant portions of the annual cycle, dominates the exchange of energy and mass across the ocean‐sea ice‐atmosphere (OSA) interface. We investigate the nature of sea ice concentration (SIC) anomalies for spatial and temporal statistical persistence ...
Jennifer V. Lukovich, David G. Barber
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dataset for IceNet's Galaxy tool - Sea ice concentration - NH

, 2023
Jean Iaquinta
openalex   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The AutoICE Challenge [PDF]

The Cryosphere
Mapping sea ice in the Arctic is essential for maritime navigation, and growing vessel traffic highlights the necessity of the timeliness and accuracy of sea ice charts.
A. Stokholm, A. Stokholm, J. Buus-Hinkler, T. Wulf, A. Korosov, R. Saldo, L. T. Pedersen, D. Arthurs, I. Dragan, I. Modica, J. Pedro, A. Debien, X. Chen, M. Patel, F. J. P. Cantu, J. N. Turnes, J. Park, L. Xu, K. A. Scott, D. A. Clausi, Y. Fang, M. Jiang, S. Taleghanidoozdoozan, N. C. Brubacher, A. Soleymani, Z. Gousseau, M. Smaczny, P. Kowalski, J. Komorowski, D. Rijlaarsdam, J. N. van Rijn, J. Jakobsen, M. S. J. Rogers, N. Hughes, T. Zagon, R. Solberg, N. Longépé, M. B. Kreiner   +37 more
doaj   +1 more source