Results 101 to 110 of about 294,753 (307)

Loss of sea ice during winter north of Svalbard [PDF]

, 2014
Sea ice loss in the Arctic Ocean has up to now been strongest during summer. In contrast, the sea ice concentration north of Svalbard has experienced a larger decline during winter since 1979. The trend in winter ice area loss is close to 10% per decade,
Aagaard K., Alexeev V. A., Beszczynska-Möller A., Cokelet E., Comiso J. C, Dee D. P., Frank Nilsen, Førland E. J., Førland E. J., Grotefendt K., Hansen E., Ingrid H. Onarheim, Ivanov V. V., Lars H. Smedsrud, Lind S., Piechura J., Polyakov I. V., Polyakov I. V., Quenouille M. H, Rainville L., Randi B. Ingvaldsen, Rudels B, Rudels B, Saloranta T. M., Sandø A. B., Schauer U., Sirevaag A., Smedsrud L. H., Untersteiner N, Årthun M.   +29 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Spatial cross-correlation of Antarctic Sea ice and seabed topography [PDF]

A time series of derived sea ice concentrations as observed about Antarctica by the Nimbus-7 Scanning Multichannel Microwave Radiometer (SMMR) satellite in 1983 is considered.
Deveaux, Richard D., Phelan, Michael J.
core   +1 more source

Phytoplankton in the Beaufort and Chukchi Seas: Distributions, Dynamics and Environmental Forcing [PDF]

, 2005
Time-series of remotely sensed distributions of phytoplankton, sea ice, surface temperature, albedo, and clouds were examined to evaluate the impact of the variability of environmental conditions and physical forcing on the phytoplankton distribution in ...
Comiso, Josefino C., Cota, Glenn F., Wang, Jian   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Pilot study and evaluation of a SMMR-derived sea ice data base [PDF]

Data derived from the Nimbus 7 scanning multichannel microwave radiometer (SMMR) are discussed and the types of problems users have with satellite data are documented. The development of software for assessing the SMMR data is mentioned. Two case studies
Anderson, M. R., Barry, R. G., Crane, R. G., Troisi, V. J., Weaver, R. L.   +4 more
core   +1 more source

Increasing fall-winter energy loss from the Arctic Ocean and its role in Arctic temperature amplification [PDF]

, 2013
Copyright © 2010 American Geophysical UnionArctic surface temperatures have risen faster than the global average in recent decades, in part due to positive feedbacks associated with the rapidly diminishing sea ice cover.
Screen, James A., Simmonds, Ian
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Sea ice concentration decline in an important Adélie penguin molt area. [PDF]

Proc Natl Acad Sci U S A, 2023
Schmidt AE, Lescroël A, Lisovski S, Elrod M, Jongsomjit D, Dugger KM, Ballard G.   +6 more
europepmc   +1 more source