Results 91 to 100 of about 294,753 (307)

Impact of melt ponds on Arctic sea ice simulations from 1990 to 2007 [PDF]

, 2012
The extent and thickness of the Arctic sea ice cover has decreased dramatically in the past few decades with minima in sea ice extent in September 2007 and 2011 and climate models did not predict this decline.
Bitz, Bitz, Brodeau, Collins, Curry, Daniel L. Feltham, Daniela Flocco, David Schroeder, Eicken, Eicken, Eisenman, Elizabeth C. Hunke, Feltham, Fetterer, Flocco, Flocco, Giles, Giles, Golden, Grenfell, Hibler, Holland, Hunke, Hunke, Intergovernmental Panel on Climate Change, Kern, Kwok, Laxon, Lipscomb, Lüthje, Markus, Maslanik, Maykut, Meier, Miller, Perovich, Perovich, Perovich, Perovich, Perovich, Perovich, Perovich, Polashenski, Rothrock, Rösel, Schweiger, Scott, Seo, Skyllingstad, Stroeve, Taylor, Thorndike, Tschudi   +52 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Sudden increase in Antarctic sea ice: Fact or artifact? [PDF]

, 2013
Copyright © 2011 American Geophysical UnionThree sea ice data sets commonly used for climate research display a large and abrupt increase in Antarctic sea ice area (SIA) in recent years.
Cavalieri, Cavalieri, Comiso, Comiso, Comiso, J. A. Screen, Markus, Meier, Meier, Parkinson, Parkinson, Rayner, Reynolds, Screen, Spreen, Stroeve, Zabel   +16 more
core   +1 more source

Verification of simulated sea-ice concentrations from sea-ice/ocean models using satellite data

, 2010
Sea-ice concentrations in the Laptev Sea simulated by the coupled North Atlantic – Arctic Ocean – Sea-Ice Model (NAOSIM) and Finite Element Sea-Ice Ocean Model (FESOM)are verified using sea-ice concentrations from AMSR-E satellite data and a polynya classification method for winter 2007/08.
Adams, Susanne, Willmes, Sascha, Heinemann, Günther, Rozman, Polona, Timmermann, Ralph, Schröder, David   +5 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Report of the first Nimbus-7 SMMR Experiment Team Workshop [PDF]

Preliminary results of sea ice and techniques for calculating sea ice concentration and multiyear fraction from the microwave radiances obtained from the Nimbus-7 SMMR were presented. From these results, it is evident that these groups used different and
Campbell, W. J., Gloersen, P.
core   +1 more source

On the influence of model physics on simulations of Arctic and Antarctic sea ice [PDF]

, 2011
Two hindcast (1983–2007) simulations are performed with the global, ocean-sea ice models NEMO-LIM2 and NEMO-LIM3 driven by atmospheric reanalyses and climatologies.
C. König Beatty, F. Massonnet, H. Goosse, M. Vancoppenolle, P. Mathiot, T. Fichefet   +5 more
core   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Towards Sea Ice Remote Sensing with Space Detected GPS Signals: Demonstration of Technical Feasibility and Initial Consistency Check Using Low Resolution Sea Ice Information

Remote Sensing, 2010
This paper presents two space detected Global Positioning System (GPS)signals reflected off sea ice and compares the returned power profiles with independent estimates of ice concentration provided by the Advanced Microwave Scanning Radiometer (AMSR-E ...
Scott Gleason
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source