Results 61 to 70 of about 40,901 (260)

Sea-ice indicators of polar bear habitat [PDF]

The Cryosphere, 2016
Nineteen subpopulations of polar bears (Ursus maritimus) are found throughout the circumpolar Arctic, and in all regions they depend on sea ice as a platform for traveling, hunting, and breeding.
H. L. Stern, K. L. Laidre, K. L. Laidre
doaj   +1 more source

On sea ice concentration anomaly coherence in the southern Beaufort Sea

Geophysical Research Letters, 2005
The circumpolar flaw lead polynya system is a region of enhanced biological productivity and for significant portions of the annual cycle, dominates the exchange of energy and mass across the ocean‐sea ice‐atmosphere (OSA) interface. We investigate the nature of sea ice concentration (SIC) anomalies for spatial and temporal statistical persistence ...
Jennifer V. Lukovich, David G. Barber
openaire   +1 more source

Super Resolution of Arctic Sea Ice Concentration

, 2021
Arctic sea ice concentration is often coarsely observed and numerically computed despite its importance for polar climate system. In this work we present three machine-learning methods to recover the original high-resolution images from the coarse-grained low-resolution counterparts.
Zhai, Jun, Bitz, Cecilia M.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of the complexity of the ocean model on the sea ice data assimilation in a coupled sea ice-ocean model

Geoscience Letters
The ocean plays a crucial role in the formation and melting of sea ice, which also affects the performance of sea ice data assimilation. To evaluate how ocean model complexity affects the assimilation performance, the sea ice model is separately coupled ...
Young-Chan Noh, Yonghan Choi, Joo-Hong Kim   +2 more
doaj   +1 more source

Evaluation of the ArcIOPS sea ice forecasts during 2021–2023

Frontiers in Earth Science
The operational sea ice forecasts from the Arctic Ice Ocean Prediction System (ArcIOPS) during 2021–2023 are validated against satellite-retrieved sea ice concentration and drift data, in situ and reanalyzed sea ice thickness data.
Xi Liang, Zhongxiang Tian, Fu Zhao, Ming Li, Na Liu, Chunhua Li   +5 more
doaj   +1 more source

Developing a deep learning forecasting system for short-term and high-resolution prediction of sea ice concentration [PDF]

The Cryosphere
There has been a steady increase in marine activity throughout the Arctic Ocean during the last few decades, and maritime end users are requesting skilful high-resolution sea ice forecasts to ensure operational safety. Different studies have demonstrated
A. F. Kvanum, A. F. Kvanum, C. Palerme, M. Müller, M. Müller, J. Rabault, N. Hughes   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Impact of the ice thickness distribution discretization on the sea ice concentration variability in the NEMO3.6-LIM3 global ocean–sea ice model [PDF]

Geoscientific Model Development, 2019
Abstract. This study assesses the impact of different sea ice thickness distribution (ITD) configurations on the sea ice concentration (SIC) variability in ocean-standalone NEMO3.6-LIM3 simulations. Three ITD configurations with different numbers of sea ice thickness categories and boundaries are evaluated against three different satellite products ...
Moreno Chamarro, Eduardo, Ortega Montilla, Pablo, Massonnet, François   +2 more
openaire   +5 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source