Results 111 to 120 of about 5,479,751 (293)

A dynamical model of Kara Sea land‐fast ice [PDF]

Journal of Geophysical Research: Oceans, 2016
AbstractThis paper introduces modifications to the traditional viscous‐plastic sea‐ice dynamical model, which are necessary to model land‐fast ice in the Kara Sea in a realistic manner. The most important modifications are an increase in the maximum viscosity from the standard value of to , and to use a solver for the momentum equation capable of ...
openaire   +2 more sources

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Using sea-level and land motion data to develop an improved glacial isostatic adjustment model for the British Isles [PDF]

, 2011
The Glacial Isostatic Adjustment (GIA) of the British Isles is of interest due to the constraints that can be provided on key model parameters such as regional ice sheet history, viscoelastic earth structure and the global meltwater (eustatic) signal ...
Bradley, Sarah Louise, BRADLEY, SARAH,LOUISE   +1 more
core  

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Intra‐population variation in the effects of sea ice reduction on an Arctic breeding bird

Ecosphere
The Arctic is warming four times faster than any other region on Earth, leading to a dramatic reduction in sea ice. Even though sea ice plays a key role in the ecology of many Arctic species, few studies have assessed the consequences of its ...
Hilde Dørum, Sébastien Descamps, Børge Moe, Bård‐Jørgen Bårdsen, Kjell Tore Hansen, Sveinn Are Hanssen, Christophe Sauser, Marika Marnela, Sebastian Gerland, Geir W. Gabrielsen   +9 more
doaj   +1 more source

Description of the Earth system model of intermediate complexity LOVECLIM version 1.2 [PDF]

, 2010
The main characteristics of the new version 1.2 of the three-dimensional Earth system model of intermediate complexity LOVECLIM are briefly described.
Munhoven, G., Campin, J.M., A. Timmermann, Janssens, I., Morales Maqueda, M. A., Morales Maqueda, M., M.-F. Loutre, Morales Maqueda, M.A., Brovkin, V., Campin, J., J.-M. Campin, Fichefet, T., M. A. Morales Maqueda, Munhoven, Guy, Pettersson, E.J., Barriat, P.-Y., Roche, D.M., Pettersson, E. J., Huybrechts, Philippe, Roche, D. M., Barriat, P., Mouchet, A., Mathieu, P.-P., Selten, F., Loutre, M.-F., Weber, S. L., I. Janssens, E. Deleersnijder, Mochet, A., P.-Y. Barriat, Roche, D.M.V.A.P.; id_orcid, Brovkin, V. ; https://orcid.org/, Brovkin, Victor V.B., Deleersnijder, E., Mathieu, P-P., Weber, S.L., R. Haarsma, Roche, D., Goelzer, Heiko, T. Fichefet, Jongma, J.I., Haarsma, R., Jongma, J., H. Renssen, H. Goelzer, Loutre, M.F., Pettersson, Erna, Goelzer, H., F. Selten, V. Brovkin, Loutre, M., B. Tartinville, Tartinville, B., Timmerman, A., H. Goosse, Pettersson, E., G. Munhoven, D. M. Roche, Campin, Jean-Michel, Campin, J.-M., A. Mouchet, Petterson, E.J., Selton, F., Timmermann, A., S. L. Weber, E. J. Pettersson, Renssen, Hans, E. Driesschaert, Loutre, Marie-France, Goosse, H., Mathieu, P., Fichefet, Thierry, Roche, Didier M., Opsteegh, T., Renssen, H., Schaeffer, M., M. Schaeffer, Huybrechts, P., Mathieu, P.P., P.-P. Mathieu, Barriat, P.Y., Driesschaert, E., Mouchet, Anne, J. Jongma, P. Huybrechts, Goosse, Hugues, T. Opsteegh, Weber, S., Barriat, Pierre Yves, Barriat, Pierre-Yves, Deleersnijder, Eric, Loutre , Marie-France, Hugues Goosse   +92 more
core   +2 more sources

Rotary 3D Printing With Integrated Electroplating

Advanced Engineering Materials, EarlyView.
A rotary material extrusion platform integrates localized copper electroplating with printing and encapsulation to fabricate cylindrical polymer–metal structures containing fully embedded, low‐resistance conductive pathways that enable internal Joule heating and thermally activated shape‐memory responses.
Antonio Zagaria, Nicola Larovere, Moslem Mohammadi, Gianluca Percoco, Ali Zolfagharian, Gianni Stano   +5 more
wiley   +1 more source

Drift-aware sea ice thickness maps from satellite remote sensing [PDF]

The Cryosphere
The standard approach to deriving gridded sea ice thickness (SIT) from satellite altimeters is to aggregate the original along-track SIT estimates over a 1-month period to achieve sufficient coverage across the Arctic.
R. Ricker, T. Lavergne, S. Hendricks, S. Paul, E. Down, M. A. Killie, M. Bocquet   +6 more
doaj   +1 more source