Results 91 to 100 of about 5,134,596 (298)

The impact of sea ice melt on the evolution of surface pCO2 in a polar ocean basin

Frontiers in Marine Science
The strong CO2 sink in Arctic Ocean plays a significant role in the global carbon budget. As a high-latitude oceanic ecosystem, the features of sea surface pCO2 and air-sea CO2 flux are significantly influenced by sea ice melt; however, our understanding
Wei Yang, Yu Zhao, Yingxu Wu, Zijie Chen, Xiang Gao, Hongmei Lin, Zhangxian Ouyang, Weijun Cai, Liqi Chen, Di Qi   +9 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Sea ice friction and Arctic sea ice dynamics

, 2010
A series of double-shear experiments were undertaken in the Environmental Test Basin at the Hamburgische Shiffbau-Versuchsanstalt (HSVA) in Hamburg. The aim of these experiments was to improve understanding of transient behaviour in sea ice friction. To this end we have fitted our experimental results to a rate- and state- dependent model of friction ...
Lishman, Ben, Sammonds, Peter, Feltham, Danny, Wilchinsky, Alex   +3 more
openaire   +1 more source

Spatiotemporal Variations in Sea Ice Albedo: A Study of the Dynamics of Sea Ice Albedo in the Sea of Okhotsk

Remote Sensing
This study utilizes a novel albedo retrieval framework combining radiative transfer modeling with scientific machine learning (RTM-SciML) to investigate sea ice dynamics in the Sea of Okhotsk. By validating albedo estimates derived from the MODIS sensor against in situ pyranometer measurements near the Hokkaido coast, we achieved a robust Pearson ...
Yingzhen Zhou, Wei Li, Nan Chen, Takenobu Toyota, Yongzhen Fan, Tomonori Tanikawa, Knut Stamnes   +6 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Using sea-level and land motion data to develop an improved glacial isostatic adjustment model for the British Isles [PDF]

, 2011
The Glacial Isostatic Adjustment (GIA) of the British Isles is of interest due to the constraints that can be provided on key model parameters such as regional ice sheet history, viscoelastic earth structure and the global meltwater (eustatic) signal ...
Bradley, Sarah Louise, BRADLEY, SARAH,LOUISE   +1 more
core  

Exploring beneath the PIG Ice Shelf with the Autosub3 AUV [PDF]

, 2009
On 31st January 2009, two numbers: “range and bearing” flashing up on a laptop screen, indicated that Autosub3 had returned from its last mission beneath the Pine Island Glacier (PIG) Ice Shelf in the Western Antarctic.
Furlong, Maaten E, White, Davie, J.R. Perrett, M. Pebody, P. Stevenson, Stevenson, Peter, Webb, Andy, McPhail, Stephen D, D. White, M. E. Furlong, S. D. McPhail, Perrett, James R, A. Webb   +12 more
core   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

On the Consistent Scaling of Terms in the Sea-Ice Dynamics Equation

Journal of Physical Oceanography, 2004
The standard way in which the sea-ice dynamics equation is used in models assumes that the wind stress and ocean drag do not depend on the sea-ice concentration. It is demonstrated that this assumption is inconsistent with the free-drift limit, and how great an effect it has in practice is examined.
Connolley, W.M., Gregory, J.M., Hunke, E., McLaren, A.J.   +3 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source