Results 81 to 90 of about 5,134,596 (298)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Voronoi Dynamics Simulation of Development of Lamellar Microstructure in Sea Ice [PDF]

, 2008
Developments of sea ice polycrystals from the sea surface are simulated in two-dimensional approximation by combining numerical methods for crystal growth, salinity diffusion and flux of heat. An anisotropic growth of ice crystals from a number of nuclei
カワノ, ヨシキ, 大橋, 鉄也, 河野, 義樹, Kawano, Yoshiki   +3 more
core   +1 more source

A large-scale high-resolution numerical model for sea-ice fragmentation dynamics [PDF]

The Cryosphere
Forecasts of sea-ice motion and fragmentation are of vital importance for all human interactions with sea ice, ranging from those involving indigenous hunters to shipping in polar regions.
J. Åström, F. Robertsen, J. Haapala, A. Polojärvi, R. Uiboupin, I. Maljutenko   +5 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Antarctic sea ice control on ocean circulation in present and glacial climates [PDF]

, 2013
All authors acknowledge support from the National Science Foundation. R.F. acknowledges support from the Breene M. Kerr Chair.In the modern climate, the ocean below 2 km is mainly filled by waters sinking into the abyss around Antarctica and in the North
Burke, Andrea, Ferrari, Raffaele, Adkins, Jess F., Jansen, Malte F., Thompson, Andrew F., Stewart, Andrew L., Jansen, Malte Friedrich, Burke, Andrea, Ph. D. Massachusetts Institute of Technology   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Sea Ice Dynamics in Foxe Basin: Formation of a Thick Dirty Seasonal Ice Cover along a Proposed Year-Round Shipping Route

Arctic Science
Foxe Basin is a shallow inland sea in the Canadian Arctic that has strong tidal dynamics and is covered by a notoriously deformed and dirty sea ice cover for 9 months a year.
David Babb, Sergei Kirillov, Ryan Galley, Jens Ehn   +3 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Recent trends in melting conditions on the Antarctic Peninsula and their implications for ice-sheet mass balance and sea level [PDF]

, 2006
Long-term records from meteorological stations on the Antarctic Peninsula show strong rising trends in the annual duration of melting conditions. In each case, the trend is statistically significant and represents a major increase in the potential for ...
Dowdeswell, J.A., Bassford, R. P., Glazovsky, A.F., Glazovsky, A. F., Siegert, M. J,, Macheret, Y.Y., Macheret, Y. Y., Vaughan, David G., J. A. Dowdeswell, David G. Vaughan, A. F. Glazovsky, Oerlemans, J., R. P. Bassford, Bassford, R.P., Y. Y. Macheret, M. J. Siegert, Siegert, M. J., Dowdeswell, J. A., Siegert, M.J., J. Oerlemans, Hoch, Günter, Dowling, Carolyn, Vaughn, Bruce H., Olofsson, Johan,, Körner, Christian, Lyons, W. Berry, Gooseff, Michael N., Fountain, Andrew G., McKnight, Diane M.   +28 more
core   +2 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source