Results 81 to 90 of about 5,354,706 (300)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Using Sea-Level Data to Constrain the Contribution of the Greenland Ice Sheet to Contemporary and Recent Sea-Level Change [PDF]

, 2010
Due to the potentially wide-reaching impacts on climate and sea-level change of a declining Greenland Ice Sheet (GrIS), the mass balance of the past decade has caused concern that the ice sheet is reacting to increased temperatures of the industrial era ...
Wake, Leanne Mary, WAKE, LEANNE,MARY
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A large-scale high-resolution numerical model for sea-ice fragmentation dynamics [PDF]

The Cryosphere
Forecasts of sea-ice motion and fragmentation are of vital importance for all human interactions with sea ice, ranging from those involving indigenous hunters to shipping in polar regions.
J. Åström, F. Robertsen, J. Haapala, A. Polojärvi, R. Uiboupin, I. Maljutenko   +5 more
doaj   +1 more source

Microbial Loop Dynamics in Antarctic Sea-Ice

, 2009
Sea-ice is a predominant feature of polar oceans and exerts a unique influence on marine ecosystems. The annual circumpolar expansion of sea-ice around Antarctica provides a stable platform for the in situ colonisation and growth of a diverse assemblage ...
Martin, Andrew Robert (11640262), null null, Andrew Robert Martin   +2 more
core   +1 more source

Calving rates at tidewater glaciers vary strongly with ocean temperature [PDF]

, 2015
TerraSAR-X data were provided by DLR (project OCE1503), and funded by the Conoco Phillips-Lundin Northern Area Program through the CRIOS project (Calving Rates and Impact on Sea level). A.L. and S.B.
Luckman, Adrian, Inall, M., Benn, Doug, Cottier, F., Benn, Doug I, Cottier, Finlo, Bevan, S., Inall, Mark, Luckman, A., Nilsen, Frank, Bevan, Suzanne, Suzanne Bevan, Nilsen, F., Adrian Luckman, Benn, Doug I; id_orcid   +14 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Numerical study of sea ice dynamics and wave-ice interactions in the marginal ice zone

, 2021
The Marginal Ice Zone (MIZ) is a highly dynamic region between the open ocean and the inner ice pack. The ice over this region is subjected to waves, introducing new forces but also changing the ice from a cohesive material to a mobile collection of ...
Auclair, Jean-Pierre
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Sea ice dynamics in Foxe Basin: formation of a thick dirty seasonal ice cover along a proposed year-round shipping route

Arctic Science
Foxe Basin is a shallow inland sea in the Canadian Arctic that has strong tidal dynamics and is covered by a notoriously deformed and dirty sea ice cover for 9 months a year.
D.G. Babb, S.K. Kirillov, R.J. Galley, J.K. Ehn   +3 more
doaj   +1 more source