Results 141 to 150 of about 4,079,930 (328)

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

New Perspectives on Observed and Simulated Antarctic Sea Ice Extent Trends Using Optimal Fingerprinting Techniques

, 2015
Using optimal fingerprinting techniques, a detection analysis is performed to determine whether observed trends in Southern Ocean sea ice extent since 1979 are outside the expected range of natural variability.
W. Hobbs, N. Bindoff, M. Raphael
semanticscholar   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Ice type matters: impacts of landfast and drift ice on body condition in a high Arctic seabird community

Frontiers in Marine Science
Sea ice, a central component of polar ecosystems, is undergoing profound changes due to climate change. In particular, the Arctic is experiencing unprecedented warming at quicker rates than other regions.
Christophe Sauser, Pierre Blévin, Olivier Chastel, Geir Wing Gabrielsen, Sveinn Are Hanssen, Erlend Lorentzen, Børge Moe, Sebastien Moreau, Kjetil Sagerup, Sebastien Descamps   +9 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The evolution of the Greenland Ice Sheet from the Last Glacial Maximum to present-day: An assessment using glaciological and Glacial Isostatic Adjustment modelling [PDF]

, 2009
In this thesis we constrain a three-dimensional thermomechanical model of Greenland ice sheet (GrIS) evolution from the Last Glacial Maximum (LGM, 21 ka BP) to the present-day using, primarily, observations of relative sea level (RSL) as well as field ...
SIMPSON, MATTHEW,JAMES,ROSS
core  

The linkages between Antarctic sea ice extent and Indian summer monsoon rainfall

, 2020
Teleconnection between the Antarctic sea ice and the tropical climate has been extensively investigated. This study examines the interannual relationship between the variability of sea ice extent in the Indian Ocean sector (20–90°E) and Indian summer ...
Samah, Azizan Abu, Chenoli, Sheeba Nettukandy, Atiqah Azhar, Siti Syairah, Kim, Seong-Joong   +3 more
core   +1 more source

Controls on Last Glacial Maximum ice extent in the Weddell Sea embayment, Antarctica

, 2017
The Weddell Sea sector of the Antarctic Ice Sheet is hypothesized to have made a significant contribution to sea‐level rise since the Last Glacial Maximum.
Pippa L. Whitehouse, M. Bentley, A. Vieli, Stewart S. R. Jamieson, Andrew S. Hein, D. Sugden   +5 more
semanticscholar   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source