Results 41 to 50 of about 11,058 (259)

The impact of snow depth, snow density and ice density on sea ice thickness retrieval from satellite radar altimetry: results from the ESA-CCI Sea Ice ECV Project Round Robin Exercise [PDF]

The Cryosphere, 2015
We assess different methods and input parameters, namely snow depth, snow density and ice density, used in freeboard-to-thickness conversion of Arctic sea ice. This conversion is an important part of sea ice thickness retrieval from spaceborne altimetry.
S. Kern, K. Khvorostovsky, H. Skourup, E. Rinne, Z. S. Parsakhoo, V. Djepa, P. Wadhams, S. Sandven   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

An Improved Algorithm for the Retrieval of the Antarctic Sea Ice Freeboard and Thickness from ICESat-2 Altimeter Data

Remote Sensing, 2022
ICESat-2 altimeter data could be used to estimate sea ice freeboard and thickness values with a higher measuring accuracy than that achievable with data provided by previous altimeter satellites.
Xiaoping Pang, Yizhuo Chen, Qing Ji, Guoyuan Li, Lijian Shi, Musheng Lan, Zeyu Liang   +6 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Seasonal and Interannual Variations in Sea Ice Thickness in the Weddell Sea, Antarctica (2019–2022) Using ICESat-2

Remote Sensing
The sea ice extent in the Weddell Sea exhibited a positive trend from the start of satellite observations in 1978 until 2016 but has shown a decreasing trend since then.
Mansi Joshi, Alberto M. Mestas-Nuñez, Stephen F. Ackley, Stefanie Arndt, Grant J. Macdonald, Christian Haas   +5 more
doaj   +1 more source

A weekly Arctic sea-ice thickness data record from merged CryoSat-2 and SMOS satellite data [PDF]

The Cryosphere, 2017
Sea-ice thickness on a global scale is derived from different satellite sensors using independent retrieval methods. Due to the sensor and orbit characteristics, such satellite retrievals differ in spatial and temporal resolution as well as in the ...
R. Ricker, R. Ricker, S. Hendricks, L. Kaleschke, X. Tian-Kunze, J. King, C. Haas, C. Haas   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Relating the Age of Arctic Sea Ice to its Thickness, as Measured during NASA’s ICESat and IceBridge Campaigns

Remote Sensing, 2016
Recent satellite observations yield estimates of the distribution of sea ice thickness across the entire Arctic Ocean. While these sensors were only placed in operation within the last few years, information from other sensors may assist us with ...
Mark A. Tschudi, Julienne C. Stroeve, J. Scott Stewart   +2 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source