Results 51 to 60 of about 122,866 (281)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Impact of assimilating a merged sea-ice thickness from CryoSat-2 and SMOS in the Arctic reanalysis
The Cryosphere, 2018 . Accurately forecasting the sea-ice thickness (SIT) in the Arctic is a major challenge. The new SIT product (referred to as CS2SMOS) merges measurements from the CryoSat-2 and SMOS satellites on a weekly basis during the winter.
Jiping Xie +2 more
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Empirical sea ice thickness retrieval during the freeze-up period from SMOS high incident angle observations [PDF]
The Cryosphere, 2014 Sea ice thickness information is important for sea ice modelling and ship operations. Here a method to detect the thickness of sea ice up to 50 cm during the freeze-up season based on high incidence angle observations of the Soil Moisture and ...
M. Huntemann +5 more
doaj +1 more source
Structural and functional characterization of chitinase from carnivorous plant Drosera adelae
FEBS Open Bio, EarlyView.A class I chitinase from the carnivorous plant Drosera adelae was expressed and purified using a yeast system, revealing high enzymatic activity. Structural analyses of the catalytic and chitin‐binding domains identified key tyrosine residues involved in substrate binding, offering insights into the enzyme's adaptation for insect digestion.
Kazunari Yoneda +7 more
wiley +1 more source
Estimation of Arctic Sea Ice Thickness Using HY-2B Altimeter Data
Remote SensingSea ice thickness is an important component of the Arctic environment, bearing crucial significance in investigations pertaining to global climate and environmental changes.
Chunyu Pang +4 more
doaj +1 more source
Sea Ice Remote Sensing—Recent Developments in Methods and Climate Data Sets
Surveys in geophysics, 2023 Sea ice monitoring by polar orbiting satellites has been developed over more than four decades and is today one of the most well-established applications of space observations.
S. Sandven +6 more
semanticscholar +1 more source
SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas +18 more
wiley +1 more source
Improving the WRF model's (version 3.6.1) simulation over sea ice surface through coupling with a complex thermodynamic sea ice model (HIGHTSI) [PDF]
Geoscientific Model Development, 2016 Sea ice plays an important role in the air–ice–ocean interaction, but it is often represented simply in many regional atmospheric models. The Noah sea ice scheme, which is the only option in the current Weather Research and Forecasting (WRF) model ...
Y. Yao, J. Huang, Y. Luo, Z. Zhao
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source