Results 61 to 70 of about 198,848 (303)

The last interglacial in the northern North Atlantic and adjacent areas: evidence for a more zonal climate than during the Holocene [PDF]

, 2011
We document climate conditions from the last interglacial optimum (LIO) or marine isotope stage 5e (MIS 5e) from terrestrial and oceanic sedimentary archives.
Bauch, Henning A., De Vernal, Anne, Eynaud, Frédérique, Fréchette, Bianca, Hillaire-Marcel, Claude, Van Nieuwenhove, Nicolas   +5 more
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

The Inversion of Three-Dimensional Ocean Temperature and Salinity Fields for the Assimilation of Satellite Observations

Journal of Marine Science and Engineering
The lack of dimensionality of ocean observations makes it difficult to utilize multi-scale data assimilation to correct model errors with limited observations.
Yueqi Zhao, Zhongjie He, Yuhang Jiang
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Analysis of a 44-year hindcast for the Mediterranean Sea: comparison with altimetry and in situ observations

Scientia Marina, 2011
We study the interannual and seasonal variability in the Mediterranean Sea over the period 1958-2004 by comparing a numerical simulation (the 1/4º ORCA-R025 G70 model run, ‘ORCA’ hereafter) with altimetry and the MEDAR temperature and salinity database ...
Enrique Vidal-Vijande, Ananda Pascual, Bernard Barnier, Jean-Marc Molines, Joaquín Tintoré   +4 more
doaj   +1 more source

Assessing the accuracy of δ^{18<\sup>O_{sw estimates from corals: lessons from simple Monte Carlo simulations}} [PDF]

, 2008
EGU2008-A-04391 Paired measurements of δ18O and Sr/Ca in coral aragonite are routinely used for deriving estimates of δ18Osw and, by extension, sea surface salinity variations over the past centuries. However, in practice, the accuracy (or the error) of
Cahyarini, S. Y., Dullo, Wolf-Christian, Hetzinger, Steffen, Pfeiffer, Miriam, Timm, O., Zinke, Jens   +5 more
core  

ARCTIC SEA SURFACE SALINITY RETRIEVAL FROM SMOS MEASURES

, 2019
IEEE International Geoscience and Remote Sensing Symposium (IGARSS 2019), 28 July - 2 August 2019, Yokohama, Japan.- 1 page ...
Martínez, Justino, Gabarró, Carolina, Olmedo, Estrella, González Gambau, Verónica, González-Haro, Cristina, Turiel, Antonio, Ballabrera-Poy, Joaquim, Bertino, Laurent, Raj, Roshin P., Xie, Jiping, Catany, Rafael, Arias Ballesteros, Manuel, Sabia, Roberto, Tang, Wenqing, Yueh, Simon   +14 more
openaire   +3 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evaporation induced convection enhances mixing in the upper ocean

Frontiers in Marine Science, 2023
The upper ocean surface layer is directly affected by the air-sea fluxes. The diurnal variations in these fluxes also cause the upper ocean mixed layer turbulence and mixing to diurnally vary. The underlying thermohaline structure also varies accordingly
Devang Falor, Bishakhdatta Gayen, Bishakhdatta Gayen, Debasis Sengupta, Debasis Sengupta, Gregory N. Ivey   +5 more
doaj   +1 more source