Results 71 to 80 of about 6,117,121 (293)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Temporal changes in the Red Sea circulation and associated water masses

, 2013
Long-term variability of the Red Sea deep water (RSDW) properties was investigated using hydrographic data stretching back to the beginning of the 19th century.
Alraddadi, Turki Metabe
core   +1 more source

Analysis of Surface Sound Duct in the Northern Shelf of the South China Sea

Shock and Vibration, 2018
The northern shelf of the South China Sea (NSSCS) is characterized by surface low-salinity water due to discharge from the Pearl River. In such an environment, the surface sound duct (SSD) is the most important duct for near-surface sonar applications ...
Ke Qu, Shengchun Piao, Jianbo Zhou, Fengqin Zhu   +3 more
doaj   +1 more source

Data driven three-dimensional temperature and salinity anomaly reconstruction of the northwest Pacific Ocean

Frontiers in Marine Science, 2023
By virtue of the rapid development of ocean observation technologies, tens of petabytes of data archives have been recorded, among which, the largest portion are those derived from the orbital satellites, embodying the character of ocean surface ...
Yuanhong Chen, Li Liu, Xueen Chen, Zhiqiang Wei, Xiang Sun, Chunxin Yuan, Zhen Gao   +6 more
doaj   +1 more source

Temporal and spatial variability of the sea surface salinity in the Nordic Seas [PDF]

Journal of Geophysical Research: Oceans, 2002
In this paper, the temporal and spatial variability of the sea surface salinity (SSS) in the Nordic Seas is investigated. The data include a Russian hydrographical database for the Nordic Seas and daily to weekly observations of salinity at Ocean Weather Station Mike (OWSM) (located at 66°N, 2°E in the Norwegian Sea).
Furevik, Tore, Bentsen, Mats, Drange, Helge, Johannessen, Johnny A., Korablev, Alexander   +4 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A 1-D modelling study of Arctic sea-ice salinity [PDF]

The Cryosphere, 2015
We use a 1-D model to study how salinity evolves in Arctic sea ice. To do so, we first explore how sea-ice surface melt and flooding can be incorporated into the 1-D thermodynamic Semi-Adaptive Multi-phase Sea-Ice Model (SAMSIM) presented by Griewank and
P. J. Griewank, D. Notz
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Baltic Sea Surface Salinity L4 maps (V.1.0) [Dataset]

, 2021
Filenames: BEC_SSS___SMOS__BAL_L4__B_YYYYMMDDT120000_0.25d_9d_REP_v1.0.nc YYYYMMDD: Day of the map Documents: Baltic+Salinity_D1.1_RDB_v1r7 Baltic+Salinity_D1.2_DUM_v2r0 Baltic+Salinity_D1.3_ATBD_v2r0BEC ftp service: We serve netCDF data by ...
González-Haro, Cristina, Turiel, Antonio, García Espriu, Aina, González Gambau, Verónica, Olmedo, Estrella   +4 more
core   +1 more source