Results 81 to 90 of about 198,848 (303)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
High resolution 3-D temperature and salinity fields derived from in situ and satellite observations [PDF]
, 2012 This paper describes an observation-based approach that efficiently combines the main components of the global ocean observing system using statistical methods.
A.-L. Dhomps +3 more
core +5 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Proceedings of US - PRC international TOGA symposium [PDF]
, 1990 Major features of the South Western Tropical Pacific are brought to light through analysis of sea surface salinity samples (23000) and temperature profiles (8500) gathered to study the 1979-1985 period. It is shown that the surface and subsurface oceanic
Delcroix, Thierry, Hénin, Christian
core
Wind-driven summer surface hydrography of the eastern Siberian shelf [PDF]
, 2005 High interannual variability of summer surface salinity over the Laptev and East Siberian Sea shelves derived from historical records of the 1950s–2000s is attributed to atmospheric vorticity variations.
Dmitrenko, Igor +3 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
North Atlantic subpolar gyre along predetermined ship tracks since 1993: a monthly data set of surface temperature, salinity, and density [PDF]
Earth System Science Data, 2018 We present a binned product of sea surface temperature, sea surface salinity, and sea surface density data in the North Atlantic subpolar gyre from 1993 to 2017 that resolves seasonal variability along specific ship routes (https://doi.org/10.6096/SSS-
G. Reverdin +9 more
doaj +1 more source
Surface salinity of the North Atlantic : can we reconstruct its fluctuations over the last one hundred years ? [PDF]
, 1994 Surface samples have been collected in the North Atlantic in the past one hundred years for determining the ocean salinity and its temperature. A large share of the data we have used were collected by merchant vessels of weather ships of European ...
Cayan, D. +6 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source