Results 81 to 90 of about 802,187 (333)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Is the global sea surface temperature rise accelerating?

Geodesy and Geodynamics, 2018
This is an exploratory investigation to search for the presence of an acceleration in global sea surface temperature rise, which is essential to identify anthropogenic contributions to the climate change during the 20th century.
H. Bâki Iz
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

ANALISIS HUBUNGAN PRODUKSI PERIKANAN TANGKAP LAUT, CURAH HUJAN, DAN SUHU PERMUKAAN LAUT DENGAN MODEL VECTOR AUTOREGRESSIVE (VAR)

E-Jurnal Matematika, 2019
NTT Province is one of the provinces with the largest marine catch fisheries production in Indonesia. Rainfall and sea surface temperature are factors that affect marine catch fisheries production.
RAMADHAN LENGGU RAMLI, I WAYAN SUMARJAYA, KARTIKA SARI   +2 more
doaj   +1 more source

Marine applications of HCMM satellite data [PDF]

Results of a limited comparison of HCMM sea surface temperature data with in situ data suggest that the HCMM data can provide a rather accurate representation of the sea surface temperature and temperature pattern.
Vukovich, F. M.
core   +1 more source

Lingulodinium machaerophorum expansion over the last centuries in the Caspian Sea reflects global warming [PDF]

, 2012
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ Author(s) 2012. This work is distributed under the Creative Commons Attribution 3.0 License.We analysed dinoflagellate cyst assemblages in four short sediment ...
Arpe, K, Chalié, F, Habibi, P, Haghani, S, Lahijani, HAK, Leroy, SAG, Makhlough, A, Nasrollahzadeh, HS, Reyss, J-L, Shah-Hosseini, M, Shahkarami, S, Tudryn, A   +11 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Implementation of Multidomain Unified Forward Operators (UFO) Within the Joint Effort for Data Assimilation Integration (JEDI): Ocean Applications [PDF]

The Joint Effort for Data assimilation Integration (JEDI) is a collaborative development led by the Joint Center for Satellite Data Assimilation (JCSDA) in conjunction with NASA, NOAA and the Department of Defense (NAVY and Air Force). The (Sea-Ice Ocean
Ebrahimi, Hamideh, Holdaway, Daniel, Mahajan, Rahul, Sluka, Travis, Vernières, Guillaume   +4 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Observational Analysis of Extratropical Cyclone Interactions with Northeast Pacific Sea Surface Temperature Anomalies [PDF]

, 2020
Briana Phillips, Larry W. O’Neill
openalex   +1 more source