Results 91 to 100 of about 9,437,769 (262)

Is the global sea surface temperature rise accelerating?

Geodesy and Geodynamics, 2018
This is an exploratory investigation to search for the presence of an acceleration in global sea surface temperature rise, which is essential to identify anthropogenic contributions to the climate change during the 20th century.
H. Bâki Iz
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Sea surface temperature and sea ice indicators on ODP Site 177-1094

, 2002
Sea surface temperature and sea ice indicators on ODP Site 177 ...
Rainer Gersonde (6961220), Gersonde, Rainer, Kunz-Pirrung, Martina, David A Hodell (6959735), Hodell, David A, Martina Kunz-Pirrung (7890827)   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Sea surface temperature of ODP Site 202-1233

, 2005
Sea surface temperature of ODP Site 202 ...
Kaiser, Jérôme, Dierk Hebbeln (6886385), Frank Lamy (6958274), Jérôme Kaiser (6958277), Lamy, Frank, Hebbeln, Dierk   +5 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Statistical analysis of global surface air temperature and sea level using cointegration methods [PDF]

Global sea levels are rising which is widely understood as a consequence of thermal expansion and melting of glaciers and land-based ice caps. Due to physically-based models being unable to simulate observed sea level trends, semi-empirical models have ...
Søren Johansen, Torben Schmith, Peter Thejll   +2 more
core  

Alkenone derived sea surface temperature reconstruction of sediment core HER_MC_MR03_3

, 2017
Alkenone derived sea surface temperature reconstruction of sediment core ...
Casado, Marta, Jaime Frigola (6974747), Belén Martrat (7883075), Pere Masqué (6969488), Joan O Grimalt (6962297), Lirer, Fabrizio, Leopoldo D Peña (6973688), Frigola, Jaime, Pena, Leopoldo D, Martrat, Belén, Mercè Bermejo Cisneros (8016851), Cacho, Isabel, Cisneros, Mercè Bermejo, Margaritelli, Giulia, Miquel Canals (6974750), Isabel Cacho (6962510), Fabrizio Lirer (7113104), Canals, Miquel, Marta Casado (114626), Giulia Margaritelli (8016854), Masqué, Pere, Grimalt, Joan O   +21 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

(Table 3) Sea surface temperature (SST) proxy data and in situ SSTs calculated from surface sediments from the Black Sea

, 2016
(Table 3) Sea surface temperature (SST) proxy data and in situ SSTs calculated from surface sediments from the Black ...
Lukas Wacker (6962867), Mollenhauer, Gesine, Wacker, Lukas, Gesine Mollenhauer (6965003), Janet Rethemeyer (6968573), Stephanie Kusch (6968567), Rethemeyer, Janet, Ellen C Hopmans (6975590), Hopmans, Ellen C, Kusch, Stephanie   +9 more
core   +1 more source