Results 91 to 100 of about 793,131 (304)

Lingulodinium machaerophorum expansion over the last centuries in the Caspian Sea reflects global warming [PDF]

, 2012
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ Author(s) 2012. This work is distributed under the Creative Commons Attribution 3.0 License.We analysed dinoflagellate cyst assemblages in four short sediment ...
Arpe, K, Chalié, F, Habibi, P, Haghani, S, Lahijani, HAK, Leroy, SAG, Makhlough, A, Nasrollahzadeh, HS, Reyss, J-L, Shah-Hosseini, M, Shahkarami, S, Tudryn, A   +11 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On the relationship between hurricane cost and the integrated wind profile [PDF]

, 2016
It is challenging to identify metrics that best capture hurricane destructive potential and costs. Although it has been found that the sea surface temperature and vertical wind shear can both make considerable changes to the hurricane destructive ...
Toumi, R, Wang, S
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Seasonal Variability of Wind, Surface Current and Sea Surface Temperature in the Eastern Seram Waters During the 2015 Super El Nino

Nekton
The eastern Seram waters are influenced by both the Seram Sea and the Banda Sea. This study aimed to examine variations in wind, surface currents, and sea surface temperature (SST) during 2015, coinciding with the super El Niño event.
Cipta Utama, Simon Tubalawony, Harold Joppie Davido Waas, Ronald Darlly Hukubun, Marlin Chrisye Wattimena   +4 more
doaj   +1 more source

Sea-surface temperature and salinity mapping from remote microwave radiometric measurements of brightness temperature [PDF]

A technique to measure remotely sea surface temperature and salinity was demonstrated with a dual frequency microwave radiometer system. Accuracies in temperature of 1 C and in salinity of part thousand for salinity greater than 5 parts per thousand were
Fedors, J. C., Hans-Juergen, C. B., Kendall, B. M.   +2 more
core   +1 more source

An assessment of the surface turbulent heat fluxes from the NCEP reanalysis over western boundary currents [PDF]

, 2002
With the completion of the NCEP-NCAR and ECMWF reanalyses there are now global representations of air-sea surface heat fluxes with sufficient spatial and temporal resolution to be useful in characterizing the air-sea interaction associated with ...
Moore, GWK, Renfrew, IA
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source