Results 111 to 120 of about 9,437,769 (262)

Retrieval of sea surface temperature from space based on modeling of infrared radiative transfer: capabilities and limitations [PDF]

, 2004
The retrieval (estimation) of sea surface temperatures (SSTs) from space-based infrared observations is increasingly performed using retrieval coefficients derived from radiative transfer simulations of top-of-atmosphere brightness temperatures (BTs ...
Merchant, Christopher J., Le Borgne, Pierre, Merchant, C. J., Le Borgne, P.   +3 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Sea surface temperature reconstruction for sediment core MD02-2515

, 2012
Sea surface temperature reconstruction for sediment core MD02 ...
Thunell, Robert C, Laetitia E Pichevin (6971918), Alan M Haywood (6983222), Haywood, Alan M, Valdes, Paul J, Paul J Valdes (6983231), van Dongen, Frank H, Pichevin, Laetitia, Singarayer, Joy S, Talbot, Helen M, McClymont, Erin L, Raja S Ganeshram (6974615), Ganeshram, Raja S, Robert C Thunell (6983177), Helen M Talbot (6975455), Erin L McClymont (6967463), Frank H van Dongen (6983219), Joy S Singarayer (6983225)   +17 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

China Merged Surface Temperature

, 2019
A new global ST dataset, the China Merged Surface Temperature (CMST) dataset is developed recently. CMST is created by merging the China-Land Surface Air Temperature (C-LSAT) with the sea surface temperature (SST) data from the Extended Reconstructed Sea
Qingxiang Li (7885262), Li, Qingxiang
core   +1 more source

Middle Pliocene sea surface temperature variability: PLIOCENE SEA SURFACE TEMPERATURE

, 2005
Estimates of sea surface temperature (SST) based upon foraminifer, diatom, and ostracod assemblages from ocean cores reveal a warm phase of the Pliocene between about 3.3 and 3.0 Ma. Pollen records and plant megafossils, although not as well dated, show evidence for a warmer climate at about the same time. Increased greenhouse forcing and altered ocean
Dowsett, Harry J., Chandler, Mark A., Cronin, Thomas M., Dwyer, Gary S.   +3 more
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Calculated sea surface temperature and UK(s)37 of sediment core MD90-963

, 1997
Calculated sea surface temperature and UK(s)37 of sediment core MD90 ...
Luc Beaufort (6961133), Bard, Edouard, Beaufort, Luc, Sonzogni, Corinne, Frauke Rostek (7835132), Corinne Sonzogni (2446018), Ganssen, Gerald M, Gerald M Ganssen (7044224), Rostek, Frauke, Édouard Bard (6976076)   +9 more
core   +1 more source

On Anomalous Sea Surface Temperatures in the Nordic Seas

Journal of Climate, 2000
Abstract Gridded sea surface temperature (SST), sea level pressure, 10-m wind field, and ice concentration data from the winters 1982–98 are used in a study of the large-scale variability of the SSTs in the Nordic Seas. Mean fields are extracted and areas of maximum variability identified.
openaire   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source