Results 81 to 90 of about 793,131 (304)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

ANALISIS HUBUNGAN PRODUKSI PERIKANAN TANGKAP LAUT, CURAH HUJAN, DAN SUHU PERMUKAAN LAUT DENGAN MODEL VECTOR AUTOREGRESSIVE (VAR)

E-Jurnal Matematika, 2019
NTT Province is one of the provinces with the largest marine catch fisheries production in Indonesia. Rainfall and sea surface temperature are factors that affect marine catch fisheries production.
RAMADHAN LENGGU RAMLI, I WAYAN SUMARJAYA, KARTIKA SARI   +2 more
doaj   +1 more source

Marine applications of HCMM satellite data [PDF]

Results of a limited comparison of HCMM sea surface temperature data with in situ data suggest that the HCMM data can provide a rather accurate representation of the sea surface temperature and temperature pattern.
Vukovich, F. M.
core   +1 more source

Interannual climate variability seen in the Pliocene Model Intercomparison Project [PDF]

, 2015
Following reconstructions suggesting weakened temperature gradients along the Equator in the early Pliocene, there has been much speculation about Pliocene climate variability.
Brierley, CM
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Is the global sea surface temperature rise accelerating?

Geodesy and Geodynamics, 2018
This is an exploratory investigation to search for the presence of an acceleration in global sea surface temperature rise, which is essential to identify anthropogenic contributions to the climate change during the 20th century.
H. Bâki Iz
doaj   +1 more source

Implementation of Multidomain Unified Forward Operators (UFO) Within the Joint Effort for Data Assimilation Integration (JEDI): Ocean Applications [PDF]

The Joint Effort for Data assimilation Integration (JEDI) is a collaborative development led by the Joint Center for Satellite Data Assimilation (JCSDA) in conjunction with NASA, NOAA and the Department of Defense (NAVY and Air Force). The (Sea-Ice Ocean
Ebrahimi, Hamideh, Holdaway, Daniel, Mahajan, Rahul, Sluka, Travis, Vernières, Guillaume   +4 more
core   +1 more source

The impact of a seasonally ice free Arctic Ocean on the temperature, precipitation and surface mass balance of Svalbard [PDF]

, 2012
The observed decline in summer sea ice extent since the 1970s is predicted to continue until the Arctic Ocean is seasonally ice free during the 21st Century. This will lead to a much perturbed Arctic climate with large changes in ocean surface energy flux.
Bamber, Jonathan L, Day, Jonathan J, Kohler, Jack, Valdes, Paul J   +3 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source