Results 141 to 150 of about 43,600 (294)

Glycolytic metabolism of CD8+ T‐cells affects susceptibility to human leukocyte antigen‐mediated abacavir‐induced hypersensitivity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Drug hypersensitivity reactions (DHRs) associated with a specific human leukocyte antigen (HLA) allotype do not manifest uniformly in all individuals within an HLA model population. This scenario highlights the complexity of predicting drug hypersensitivity reaction risk without considering additional factors ...
Takeshi Susukida   +7 more
wiley   +1 more source

SLPI/FBW7/c‐Myc Axis Reduces Gemcitabine Sensitivity in PDAC by Enhancing Glycolysis and Impairing NK Cell Immunity

open access: yesCancer Science, EarlyView.
SLPI reduces the sensitivity of PDAC to gemcitabine by competing with FBW7 for binding to c‐Myc, thereby disrupting FBW7‐dependent ubiquitination and proteasomal degradation of c‐Myc, leading to increased c‐Myc stability and expression. SLPI knockdown could significantly increase gemcitabine sensitivity to gemcitabine‐induced direct cytotoxicity and NK
Haofei Chen   +7 more
wiley   +1 more source

Fecundity, survival, and growth of the seahorse Hippocampus ingens (Pisces: Syngnathidae) under semi-controlled conditions</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista de Biología Tropical</i>, 2006 </span><br><span class="r_content">Estudiamos la fecundidad, supervivencia, y crecimiento del caballito de mar, Hippocampus ingens en condiciones semi-controladas. Tres machos reproductores silvestres de 14.8, 24.5 y 32.0 g produjeron 1 598, 1 703 y 1 658 jóvenes.</span><br><span class="r_sub"><i>A.A Ortega-Salas, H Reyes-Bustamante</i></span><br><small><a href="https://doaj.org/article/8691cd04f03f4631a8f6ec3c4d7a66ae" target="_blank" rel="nofollow" title="doaj.org/article/8691cd04f03f4631a8f6ec3c4d7a66ae">doaj</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1111/cas.70374" target="_blank" rel="nofollow">SOD2‐Superoxide Metabolic Axis Regulates Mitophagy and Modulates TKIs Sensitivity in Head and Neck Squamous Cell Carcinoma</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Cancer Science, EarlyView.</i></span><br><span class="r_content">Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...</span><br><span class="r_sub"><i>Wan‐Hang Zhou<span id="ma_5" style="display:none">, Shuo‐Jin Huang, An‐Xun Wang</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+2 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1111/cas.70374?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1111/cas.70374?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1111%2Fcas.70374" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1111/cas.70374'); alert('Copied the doi');">copy doi</a> <small>(10.1111/cas.70374)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1111/cpr.70207" target="_blank" rel="nofollow">Cortical‐Hypothalamic Assembloids Uncover the Cortical Regulation of Hypothalamic Responses to Fatty Acid</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Cell Proliferation, EarlyView.</i></span><br><span class="r_content">By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.</span><br><span class="r_sub"><i>Mengdan Tao<span id="ma_6" style="display:none">, Xiaowen Du, Qi Chen, Wenxin Mu, Shuning Lou, Xu Zhang, Min Xu, Jiting Li, Yuxuan Guo, Wanying Zhu, Yan Liu</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+10 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1111/cpr.70207?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1111/cpr.70207?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1111%2Fcpr.70207" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1111/cpr.70207'); alert('Copied the doi');">copy doi</a> <small>(10.1111/cpr.70207)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1111/cpr.70221" target="_blank" rel="nofollow">SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Cell Proliferation, EarlyView.</i></span><br><span class="r_content">This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).</span><br><span class="r_sub"><i>Yang Yang<span id="ma_7" style="display:none">, Juan He, Jing Zheng, Bing Shao, Lixin Shi, Miao Zhang</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_7')">+5 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1111/cpr.70221?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1111/cpr.70221?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.1111%2Fcpr.70221" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1111/cpr.70221'); alert('Copied the doi');">copy doi</a> <small>(10.1111/cpr.70221)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1016/j.cub.2009.11.032" target="_blank" rel="nofollow">Seahorse revelations</a> <b><a href="http://www.cell.com/article/S0960982209020478/pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Current Biology</i>, 2009 </span><br><small><a href="https://explore.openaire.eu/search/publication?pid=10.1016%2Fj.cub.2009.11.032" target="_blank" rel="nofollow" title="openaire.eu/search/publication?pid=10.1016%2Fj.cub.2009.11.032">openaire</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1016%2Fj.cub.2009.11.032" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1016/j.cub.2009.11.032'); alert('Copied the doi');">copy doi</a> <small>(10.1016/j.cub.2009.11.032)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1111/cura.70030" target="_blank" rel="nofollow">A Wider View: Amie Siegel's Panorama and the Role of Contemporary Art in Natural History Museum Critique and Practice</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Curator: The Museum Journal, EarlyView.</i></span><br><span class="r_content">ABSTRACT In Panorama, artist Amie Siegel montaged films made by Carnegie Museum of Natural History (CMNH) staff in the 1930s–1970s when documenting their research expeditions and exhibition projects, along with her own footage shot in the museum. Displayed at Carnegie Museum of Art in 2023–2024, the exhibition made visible the often hidden labors of ...</span><br><span class="r_sub"><i>Deirdre Madeleine Smith</i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1111/cura.70030?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1111/cura.70030?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1111%2Fcura.70030" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1111/cura.70030'); alert('Copied the doi');">copy doi</a> <small>(10.1111/cura.70030)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1111/febs.70461" target="_blank" rel="nofollow">The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>The FEBS Journal, EarlyView.</i></span><br><span class="r_content">Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.</span><br><span class="r_sub"><i>Michaela Veliova<span id="ma_10" style="display:none">, Caroline M. Ferreira, Katrina P. Montales, Francisco Villalobos, Alexandra J. Brownstein, Rebeca Acín‐Pérez, Gabrielly S. Ferreira, Anthony E. Jones, Linsey Stiles, Ajit S. Divakaruni, Marc Liesa, Orian S. Shirihai, Marcus F. Oliveira</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+12 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1111/febs.70461?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1111/febs.70461?mi=2or9o2m&af=R&AllField=seahorse&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1111%2Ffebs.70461" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1111/febs.70461'); alert('Copied the doi');">copy doi</a> <small>(10.1111/febs.70461)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-hippocampus/" class="suggestion"onclick="show_loader();"><b>hippocampus</b></a><br/><a href="/q-animals/" class="suggestion"onclick="show_loader();"><b>animals</b></a><br/><a href="/q-male_pregnancy/" class="suggestion"onclick="show_loader();"><b>male pregnancy</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-aquaculture/" class="suggestion"onclick="show_loader();"><b>aquaculture</b></a><br/><a href="/q-14._life_underwater/" class="suggestion"onclick="show_loader();"><b>14. life underwater</b></a><br/><a href="/q-smegmamorpha/" class="suggestion"onclick="show_loader();"><b>smegmamorpha</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-%3Ci%3Ehippocampus%3C%2Fi%3E/" class="suggestion"onclick="show_loader();"><b><i>hippocampus</i></b></a><br/><a href="/q-marine_biology/" class="suggestion"onclick="show_loader();"><b>marine biology</b></a><br/><a href="/q-oxidative_stress/" class="suggestion"onclick="show_loader();"><b>oxidative stress</b></a><br/></div></div></div><div class="pagenav"><a href="/q-seahorse/p-14/" rel="nofollow"><b>previous</b></a>   <a href="/q-seahorse/p-13/" rel="nofollow">13</a>  <a href="/q-seahorse/p-14/" rel="nofollow">14</a>  <b>15</b>  <a href="/q-seahorse/p-16/" rel="nofollow">16</a>  <a href="/q-seahorse/p-17/" rel="nofollow">17</a>   <a href="/q-seahorse/p-16/" id="next" rel="nofollow"><b>next</b></a> </div><br></div> </div> <script>document.getElementById('loadingGif').style.display='none';</script><div style="width: 100%; height: 40px; bottom: 0px; background-color: #f5f5f5;"><div style="padding-left: 15px; padding-top: 10px"> <a href="/" rel="nofollow">Home</a> - <a href="/page-about/" rel="nofollow">About</a> - <a href="/page-disclaimer/" rel="nofollow">Disclaimer</a> - <a href="/page-privacy/" rel="nofollow">Privacy</a> </div></div> <link rel="stylesheet" href="//ajax.googleapis.com/ajax/libs/jqueryui/1.11.4/themes/smoothness/jquery-ui.min.css"/> </body> </html>