Results 141 to 150 of about 4,985 (284)
Cancer Science, EarlyView.Our findings provide compelling evidence that the SOD2‐superoxide metabolic axis functions as a mitochondrial redox checkpoint that governs mitophagy and ultimately shapes TKI sensitivity. ABSTRACT Superoxide dismutase 2 (SOD2) has been implicated in head and neck squamous cell carcinoma (HNSCC), yet its mechanistic contribution in regulating tumor ...
Wan‐Hang Zhou +2 more
wiley +1 more source
Cell Proliferation, EarlyView.By assembling cortical‐hypothalamic circuits, we show that cortical input protects hypothalamic neurons from fatty acid‐induced damage, which activates PGC1α to boost mitochondrial function. This reveals a cortico‐hypothalamic axis that defends against metabolic stress.
Mengdan Tao +10 more
wiley +1 more source
SCD2 Alleviates Diabetes‐Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism
Cell Proliferation, EarlyView.This study reveals a novel mechanism of microglial metabolic dysfunction in diabetic cognitive impairment. Defective SCD2 disrupts monounsaturated fatty acid (MUFA) metabolism, triggering mitochondrial oxidative phosphorylation dysfunction and leading to abnormal lipid droplet accumulation (marked by PLIN2).
Yang Yang +5 more
wiley +1 more source
Curator: The Museum Journal, EarlyView.ABSTRACT In Panorama, artist Amie Siegel montaged films made by Carnegie Museum of Natural History (CMNH) staff in the 1930s–1970s when documenting their research expeditions and exhibition projects, along with her own footage shot in the museum. Displayed at Carnegie Museum of Art in 2023–2024, the exhibition made visible the often hidden labors of ...
Deirdre Madeleine Smith
wiley +1 more source
The malate–aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes
The FEBS Journal, EarlyView.Brown fat cells burn lipids within their mitochondria to generate heat. This process involves two energy “shuttles,” one of which is naturally blocked during heat production. We found that the second shuttle (MASh) is not required to generate heat. However, when MASh is disabled, the fatty acids meant for fuel are instead converted back into stored fat.
Michaela Veliova +12 more
wiley +1 more source
The FEBS Journal, EarlyView.Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia +7 more
wiley +1 more source
Journal of Fish Biology, EarlyView.Abstract Knowledge on the ecology and life‐history traits of coastal marine species is vital to inform their conservation and management, especially as their coastal habitats come under increasing threats. However, such data have never been collated for four of the five families in the suborder Syngnathoidei—the close relatives of the better‐studied ...
Syd J. Ascione +3 more
wiley +1 more source
Novel Mycobacterium Species in Seahorses with Tail Rot
Emerging Infectious Diseases, 2011 José Luis Balcázar +2 more
doaj +1 more source
Lipid Profiles and Fatty Acid Positional Distribution in Two Farmed Seahorse Species by Untargeted Lipidomics and Enzymatic Hydrolysis. [PDF]
Biology (Basel)Bi T +9 more
europepmc +1 more source