Results 81 to 90 of about 4,985 (284)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

High density, early maturing, and morphometrically unique Hippocampus erectus population makes a Bahamian pond a priority site for conservation

Endangered Species Research, 2019
Anchialine pond habitats are frequently associated with biota that can differ dramatically from nearby coastal systems. In this study, we investigated lined seahorses Hippocampus erectus by season, size, and sex across a tidal lake on the island of ...
Masonjones, H, Rose, E, Elson, J, Roberts, B, Curtis-Quick, J   +4 more
doaj   +1 more source

Camouflage of the seahorse Hippocampus reidi with plastic debris : an unusual type of protective resemblance [PDF]

, 2015
Camouflage is one of the strategies of reef fishes, in which they mimic other species or use the background to match the combination of their colors and textures (Randall 2005).
Barreiros, João P., Marques, Simone
core   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Isolation, identification, and pathogenic potential of Bacillus cereus from diseased big‐belly seahorse Hippocampus abdominalis

Journal of the World Aquaculture Society
Members of Bacillus cereus have been documented as important bacterial pathogens in aquaculture. However, scarce information is available on B. cereus isolates as causal pathogens of big‐belly seahorses Hippocampus abdominalis. In the present study, a B.
Chunlei Gai, Chenhao Teng, Yueqi Yang, Yiyao Liu, Haijing Jie, Youhong Wang, Haibin Ye, Haipeng Cao   +7 more
doaj   +1 more source

Spermatogenesis and sperm structure in the black-striped pipefish Syngnathus abaster (Teleostei, Syngnathidae) = Spermatogenesi e struttura degli spermatozoi in Syngnathus abaster (Teleostei, Synghathidae) [PDF]

, 2010
The gonads of adult males of the black-striped pipejish Syngnathus abaster were observed during the reproductive season to describe mature sperm both quantitativel/y and qualitatively.
Addis, Alberto, Biagi, Francesca, Carcupino, Marcella, Corso, Gavina   +3 more
core  

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Bycatch of lined seahorses (Hippocampus erectus) in a Gulf of Mexico shrimp trawl fishery [PDF]

, 2003
Bycatch studies have largely ignored population level effects on fish species of little commercial interest. Here we analyze bycatch of the lined seahorse (Hippocampus erectus) in the bait-shrimp trawl fishery in Hernando Beach, Florida, providing the ...
Baum, Julia K., Meeuwig, Jessica J., Vincent, Amanda C. J.   +2 more
core  

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

The Copepod/Artemia Trade-Off in the Culture of Long Snouted Seahorse Hippocampus guttulatus

Fishes
This study evaluated the effects of copepod use and copepod conditioning strategies on the growth and survival of long-snouted seahorse (Hippocampus guttulatus) juveniles from 1 to 60 days post-parturition (DPP).
Jorge Palma, Ismael Hachero-Cruzado, Miguel Correia, José Pedro Andrade   +3 more
doaj   +1 more source