Results 101 to 110 of about 9,393,101 (284)
A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück +13 morewiley +1 more sourceIn vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow +10 morewiley +1 more sourceStrangelet search at RHIC
, 2004 Two position sensitive Shower Maximum Detector (SMDs) for Zero-Degree
Calorimeters (ZDCs) were installed by STAR before run 2004 at both upstream and
downstream from the interaction point along the beam axis where particles with
small rigidity are swept ...Adams, J, Aggarwal, M M, Ahammed, Z, Amonett, J, Anderson, B D, Arkhipkin, D, Averichev, G S, Badyal, S K, Bai, Y, Balewski, J, Barannikova, O, Barnby, L S, Baudot, J, Bekele, S, Belaga, V V, Bellingeri-Laurikainen, A, Bellwied, R, Berger, J, Bezverkhny, B I, Bharadwaj, S, Bhasin, A, Bhati, A K, Bhatia, V S, Bichsel, H, Bielcik, J, Bielcikova, J, Billmeier, A, Bland, L C, Blyth, C O, Blyth, S L, Bonner, B E, Botje, M, Boucham, A, Bouchet, J, Brandin, A V, Bravar, A, Bystersky, M, Cadman, R V, Cai, X Z, Caines, H, Calderón de la Barca-Sanchez, M, Castillo, J, Catu, O, Cebra, D, Chajecki, Z, Chaloupka, P, Chattopadhyay, S, Chen, H F, Chen, J H, Chen, Y, Cheng, J, Cherney, M, Chikanian, A, Choi, H A, Christie, W, Coffin, J P, Cormier, T M, Cosentino, M R, Cramer, J G, Crawford, H J, Das, D, Das, S, Daugherity, M, De Moura, M M, De Phillips, M, Dedovich, T G, Derevshchikov, A A, Didenko, L, Dietel, T, Dogra, S M, Dong, W J, Dong, X, Draper, J E, Du, F, Dubey, A K, Dunin, V B, Dunlop, J C, Dutta-Majumdar, M R, Eckardt, V, Edwards, W R, Efimov, L G, Emelianov, V, Engelage, J, Eppley, G, Erazmus, B, Estienne, M, Fachini, P, Faivre, J, Fatemi, R, Fedorisin, J, Filimonov, K, Filip, P, Finch, E, Fine, V, Fisyak, Yu, Fornazier, K S F, Fu, J, Gagliardi, C A, Gaillard, L, Gans, J, Ganti, M S, Geurts, F, Ghazikhanian, V, Ghosh, P, González, J E, Gorbunov, Y G, Gos, H, Grachov, O, Grebenyuk, O, Grosnick, D P, Guertin, S M, Guo, Y, Gupta, N, Gutíerrez, T D, Hallman, T J, Hamed, A, Hardtke, D, Harris, J W, Heinz, M, Henry, T W, Hepplemann, S, Hippolyte, B, Hirsch, A, Hjort, E, Hoffmann, G W, Horner, M J, Huang, H Z, Huang, S L, Hughes, E W, Humanic, T J, Igo, G, Ishihara, A, Jacobs, P, Jacobs, W W, Jiang, H, Jones, P G, Judd, E G, Kabana, S, Kang, K, Kaplan, M, Keane, D, Kechechyan, A, Khodyrev, V Yu, Kim, B C, Kiryluk, J, Kisiel, A, Kislov, E M, Klay, J, Klein, S R, Koetke, D D, Kollegger, T, Kopytine, M, Kotchenda, L, Kowalik, K L, Kravtsov, P, Kravtsov, V I, Krämer, M, Krüger, K, Kuhn, C, Kulikov, A I, Kumar, A, Kutuev, R K, Kuznetsov, A A, Lamont, M A C, Landgraf, J M, Lange, S, Laue, F, Lauret, J, Le Vine, M J, Lebedev, A, Lednicky, R, Lee, C H, Lehocka, S, Li, C, Li, Q, Li, Y, Lin, G, Lindenbaum, S J, Lisa, M A, Liu, F, Liu, H, Liu, J, Liu, L, Liu, Q J, Liu, Z, Ljubicic, T, Llope, W J, Long, H, Longacre, R S, Love, W A, Lu, Y, Ludlam, T, Lynn, D, López-Noriega, M, Ma, G L, Ma, J G, Ma, Y G, Magestro, D, Mahajan, S, Mahapatra, D P, Majka, R, Mangotra, L K, Manweiler, R, Margetis, S, Markert, C, Martin, L, Marx, J N, Matis, H S, Matulenko, Yu A, McClain, C J, McShane, T S, Meissner, F, Melnik, Yu M, Meschanin, A, Miller, M L, Minaev, N G, Mironov, C, Mischke, A, Mishra, D K, Mitchell, J, Mohanty, B, Molnár, L, Moore, C F, Morozov, D A, Munhoz, M G, Nandi, B K, Nayak, S K, Nayak, T K, Nelson, J M, Netrakanti, P K, Nikitin, V A, Nogach, L V, Nurushev, S B, Odyniec, Grazyna Janina, Ogawa, A, Okorokov, V, Oldenburg, M, Olson, D, Pal, S K, Panebratsev, Yu A, Panitkin, S Y, Pavlinov, A I, Pawlak, T, Peitzmann, T, Perevozchikov, V, Perkins, C, Peryt, W, Petrov, V A, Phatak, S C, Picha, R, Planinic, M, Pluta, J, Porile, N, Porter, J, Poskanzer, A M, Potekhin, M V, Potrebenikova, E V, Potukuchi, B V K S, Prindle, D, Pruneau, C A, Putschke, J, Rakness, G, Raniwala, R, Raniwala, S, Ravel, O, Ray, R L, Razin, S V, Reichhold, D M, Reid, J G, Reinnarth, J, Renault, G, Retière, F, Ridiger, A, Ritter, H G, Roberts, J B, Rogachevski, O V, Romero, J L, Rose, A, Roy, C, Ruan, L, Russcher, M J, Sahoo, R, Sakrejda, I, Salur, S, Sandweiss, J, Sarsour, M, Savin, I, Sazhin, P S, Schambach, J, Scharenberg, R P, Schmitz, N, Schweda, K, Seger, J, Selyuzhenkov, I, Sen-Gupta, A, Seyboth, P, Shahaliev, E, Shao, M, Shao, W, Sharma, M, Shen, W Q, Shestermanov, K E, Shimansky, S S, Sichtermann, E P, Simon, F, Singaraju, R N, Smirnov, N, Snellings, R, Sood, G, Sowinski, J, Speltz, J, Spinka, H M, Srivastava, B, Stadnik, A, Stanislaus, T D S, Stock, R, Stolpovsky, A, Strikhanov, M N, Stringfellow, B C, Suaide, A A P, Sugarbaker, E R, Sumbera, M, Surrow, B, Swanger, M, Symons, T J M, Szanto de Toledo, A, Szeliga, B, Sørensen, P, Tai, A, Takahashi, J, Tang, A H, Tarnowsky, T J, Thein, D, Thomas, J H, Timmins, A R, Timoshenko, S, Tokarev, M, Trainor, T A, Trentalange, S, Tribble, R E, Tsai, O D, Ulery, J, Ullrich, T, Underwood, D G, Van Buren, G, Van der Kolk, N, Van der Molen, A M, Van Leeuwen, M, Varma, R, Vasilev, A N, Vasilevski, I M, Vernet, R, Vigdor, S E, Viyogi, Y P, Vokal, S, Voloshin, S A, Waggoner, W T, Wang, F, Wang, G, Wang, X L, Wang, Y, Wang, Z M, Ward, H, Watson, J W, Webb, J C, Westfall, G D, Wetzler, A, Whitten, C, Wieman, H, Wissink, S W, Witt, R, Wood, J, Wu, J, Xu, N, Xu, Z, Xu, Z Z, Yamamoto, E, Yepes, P, Yoo, I K, Yurevich, V I, Zborovský, I, Zhang, H, Zhang, W M, Zhang, Y, Zhang, Z P, Zhong, C, Zoulkarneev, R, Zoulkarneeva, Y, Zubarev, A N, Zuo, J X +389 morecore +1 more sourceDCU search runs at MediaEval 2012: search and hyperlinking task [PDF]
, 2012 We describe the runs for our participation in the Search
sub-task of the Search and Hyperlinking Task at MediaEval
2012. Our runs are designed to form a retrieval baseline by using time-based segmentation of audio transcripts incorporating pause ...Eskevich, Maria, Jones, Gareth J.F.core Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy. Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck +12 morewiley +1 more source
