Results 41 to 50 of about 71,650 (258)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Functionality of the Search and Rescue Transponder (SART) in Maritime Search and Rescue Actions

Applied Sciences
In this article, the authors present contemporary problems in search and rescue operations at sea. The research focuses on the detection of the SART (Search and Rescue Transponder) device.
Marzena Malyszko, Miroslaw Wielgosz, Brunon Rzepka   +2 more
doaj   +1 more source

Multipurpose UAV for search and rescue operations in mountain avalanche events

Geomatics, Natural Hazards & Risk, 2017
This paper presents a multipurpose UAV (unmanned aerial vehicle) for mountain rescue operations. The multi-rotors based flying platform and its embedded avionics are designed to meet environmental requirements for mountainous terrain such as low ...
Mario Silvagni, Andrea Tonoli, Enrico Zenerino, Marcello Chiaberge   +3 more
doaj   +1 more source

Rescue blankets hamper thermal imaging in search and rescue missions

SN Applied Sciences, 2020
Thermal imaging for unmanned aerial vehicles is used to search for victims in poor visibility conditions. We used a gimbal-mounted camera for thermo-radiation measurements of body temperature from persons covered with rescue blankets in the hibernal ...
Markus Isser, Hannah Kranebitter, Andreas Kofler, Gernot Groemer, Franz J. Wiedermann, Wolfgang Lederer   +5 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Development of Maritime Search, Rescue and Salvage Equipment

中国工程科学
Maritime search, rescue, and salvage, as the last line of defense for maritime safety, provide a reliable guarantee for the construction of a national transport system and the sustainable development of marine economy.
Gong Yongjun , Sun Yuqing , Li Huajun , Dong Chuanming , Zhang Zengmeng   +4 more
doaj   +1 more source

Research of Insertion Mechanism of Flexible Search and Rescue Robot

MATEC Web of Conferences, 2015
Due to various factors, the global scope disaster events occur inevitably every year. Terrorism, natural disasters or destructive earthquakes tend to cause a large number of people buried in the ruins of buildings.
Shen Linyong, Zhu Qian, Qiu Ya, Cao Yuanfei, Ding Hang   +4 more
doaj   +1 more source

Search and Rescue Organizations and National Medical Rescue Teams (NMRT)

Doğal Afetler ve Çevre Dergisi, 2017
Disaster is a generic name given to an event causing physical, economic and social losses for people and it stops or interrupts the normal life and actions of the people.
Mücahit Günaydın, Özgür Tatlı, Esra Ersöz Genç   +2 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source