Results 31 to 40 of about 103,371 (308)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
IEEE AccessOnline content availability, commercial viability, and technological advancements for English and European languages direct mainstream search engines to prioritize the search results of these high-resource languages.
Muhammad Amir Mehmood, Bilal Tahir
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Knowledge Management for Injection Molding Defects by a Knowledge Graph
Applied Sciences, 2022 Injection molding is a technique with a high knowledge content. However, most of the injection molding knowledge is stored in books, and it is difficult for personnel to clarify the influence of the different factors.
Zhe-Wei Zhou +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Antecedents and Outcomes of Search Engines Loyalty: Designing a model of Iranian Users Loyalty
تحقیقات بازار یابی نوین, 2013 This paper aims to design proposed model for search engine designers to promote loyalty levels of search engine users. This is a descriptive survey study. The statistical population of the research is composed of Ferdowsi University students.
Alireza Hadadian +3 more
doaj
E-Jurnal Manajemen, 2019 Tujuan dari penelitian ini adalah untuk meneliti pengaruh ekspektasi kinerja, ekspektasi usaha dan faktor sosial terhadap niat menggunakan search engine advertising. Penelitian ini dilakukan terhadap Pelaku UMKM di Provinsi B gali.
Muhammad Azhari Dadas
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Special Intelligent Search Engine
Iranian Journal of Information Processing & Management, 2011 In this paper Special Intelligent Search Engine (SISE) design has been introduced. Also System architecture and methods of this component of its intelligent search engine and features have been described.
Reza Sarabadani, Hossein Shirazi
doaj
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source