Results 101 to 110 of about 2,143,335 (271)

The loss of a child, bereavement and the search for meaning: A systematic review of the most recent parental interventions. [PDF]

Curr Psychol, 2022
Pelacho-Rios L, Bernabe-Valero G.
europepmc   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

The relationship between identity styles and presence and searching for meaning of life

مجله علوم روانشناختی, 2016
This research aimed to investigate the relationship between identity styles and the presence and searching for meaning of life. The method was descriptive and correlation. The population was undergraduate students studying in Shahid Chamran university of
Abbas Rahiminezhad, Mohsen Zalizadeh, Ahmad Alipour   +2 more
doaj  

The silent face of school dropout: When school loses its meaning

Encyclopaideia
The phenomenon of early school leaving has worrying dimensions in Italy, both in its explicit (according to recent ISTAT data from 2023 on Early Leaving From Education And Training) and implicit form (as shown by the latest INVALSI Report of 2024 ...
Antonella Arioli
doaj   +1 more source

How the COVID-19 Pandemic and its Consequences Affect the Presence of and Search for Meaning of Life: A Longitudinal Study. [PDF]

J Happiness Stud, 2023
Baños RM, Desdentado L, Vara MD, Escrivá-Martínez T, Herrero R, Miragall M, Tomás JM.   +6 more
europepmc   +1 more source

Hannah Arendt: the search for some meaning on the Jewish question [PDF]

, 2010
La filosofía de Hannah Arendt es una propuesta que trata de dar remedio a los males de la política apostando por la democracia esencial. En la Europa de los años treinta del pasado siglo el totalitarismo era, sin duda, el mayor mal que jamás la política ...
Rodríguez Ortiz, M. Victoria
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Towards Meaning in Life: A Path Analysis Exploring the Mediation of Career Adaptability in the Associations of Self-Esteem with Presence of Meaning and Search for Meaning. [PDF]

Int J Environ Res Public Health, 2022
Gori A, Topino E, Svicher A, Di Fabio A.
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source