Results 71 to 80 of about 198,614 (250)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Beyond radicalization: the 3N model and its application to criminal attitudes in high-risk contexts
Frontiers in PsychologyIntroductionThis research integrates criminological and psychological literature by applying the 3N model of radicalization to predict criminal attitudes. Specifically, we conceptualize “need” as the search for meaning, “networks” as deviant associations,
Jocelyn J. Bélanger +7 more
doaj +1 more source
The loss of a child, bereavement and the search for meaning: A systematic review of the most recent parental interventions. [PDF]
Curr Psychol, 2022 Pelacho-Rios L, Bernabe-Valero G.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The relationship between identity styles and presence and searching for meaning of life
مجله علوم روانشناختی, 2016 This research aimed to investigate the relationship between identity styles and the presence and searching for meaning of life. The method was descriptive and correlation. The population was undergraduate students studying in Shahid Chamran university of
Abbas Rahiminezhad +2 more
doaj
The silent face of school dropout: When school loses its meaning
EncyclopaideiaThe phenomenon of early school leaving has worrying dimensions in Italy, both in its explicit (according to recent ISTAT data from 2023 on Early Leaving From Education And Training) and implicit form (as shown by the latest INVALSI Report of 2024 ...
Antonella Arioli
doaj +1 more source
How the COVID-19 Pandemic and its Consequences Affect the Presence of and Search for Meaning of Life: A Longitudinal Study. [PDF]
J Happiness Stud, 2023 Baños RM +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Towards Meaning in Life: A Path Analysis Exploring the Mediation of Career Adaptability in the Associations of Self-Esteem with Presence of Meaning and Search for Meaning. [PDF]
Int J Environ Res Public Health, 2022 Gori A, Topino E, Svicher A, Di Fabio A.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source