Results 101 to 110 of about 17,504,389 (343)
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Nonstandard Foundations of Equilibrium Search Models [PDF]
We develop an equilibrium sequential search model which includes most of the literature as special cases. In particular, the model can accommodate heterogeneity in buyers’ search costs and demand functions and firms’ cost functions, with general demand ...
Michael T. Rauh
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Improving Exploratory Search Interfaces: Adding Value or Information Overload?
, 2008 One method for supporting more exploratory forms of search has been to include a compound of new interface features, such as facets, previews, collection points, synchronous communication, and note-taking spaces, within a single search interface.
Wilson, Max L., schraefel, m.c.
core +1 more source
Minimum Time Search in Uncertain Dynamic Domains with Complex Sensorial Platforms
Sensors, 2014 The minimum time search in uncertain domains is a searching task, which appears in real world problems such as natural disasters and sea rescue operations, where a target has to be found, as soon as possible, by a set of sensor-equipped searchers.
Pablo Lanillos +3 more
doaj +1 more source
Discrete Mathematics, 1992 This paper gives a brief survey of simulated annealing and genetic local search algorithms applied to covering and packing problems in coding theory.
Aarts, E.H.L., Laarhoven, van, P.J.M.
openaire +3 more sources
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Smart Search Engine For Information Retrieval [PDF]
, 2009 This project addresses the main research problem in information retrieval and semantic search. It proposes the smart search theory as new theory based on hypothesis that semantic meanings of a document can be described by a set of keywords.
SUN, LEILEI
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source