Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
An Interdisciplinary Inquiry into the Foundations of Trademark Law [PDF]
The assessment of any legal system, such as trademark law, requires a comprehensive understanding of that system, and this can be made possible only through awareness of the objectives and foundations of that system. This awareness in trademark law helps
Sh. Kasnavi
doaj +1 more source
Correction of requests in the information system decision support
Objectives. The problem of mathematical modeling and algorithmization of the processes of correction of requests in the system of information support for decision-making is being solved.
S. F. Lipnitsky
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Sociology of Alcohol Consumption – In Search of a Theory
Alcohol consumption takes place in society and because of society. The “social” aspect of this phenomenon gives a meaning that manifests itself in the framework of interaction.
Erik Brezovec
doaj
Activity theory: A framework for analysing intercultural academic activity [PDF]
This article suggests that Activity Theory (AT) can be applied as a holistic framework to analyse the complex sociocultural issues that arise when academics wish to engage in collaborative activity across institutional and cultural boundaries.
Barnard, Roger, 2245
core
Weed Search and Control: Theory and Application [PDF]
The detectability of invasive organisms influences the costs and benefits of alternative control strategies, and the feasibility of eradicating an infestation.
Spring, Daniel +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Contrasting theories of life: Historical context, current theories. In search of an ideal theory
Most attempts to define life have concentrated on individual theories, mentioning others hardly at all, but here we compare all of the major current theories.
A. Cornish-Bowden, M. Cárdenas
semanticscholar +1 more source

