Results 51 to 60 of about 7,293 (214)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
In search of a nativist theory of second language acquisition
Per Linguam : A Journal of Language Learning, 1991 This article illustrates the search for a theory of second language acquisition. It is the task of the applied linguist to investigate any discipline which can shed light on this problem.
Van der Wait, Johann L.
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Neural architecture search applying optimal stopping theory
Frontiers in Artificial IntelligenceNeural architecture search (NAS) exploration requires tremendous amounts of computational power to properly explore. This makes exploration of modern NAS search spaces impractical for researchers due to the infrastructure investments required and the ...
Matthew Sheehan, Oleg Yakimenko
doaj +1 more source
An [Imperfect] Case for Dyadic Research in Pediatric Psychosocial Oncology
Pediatric Blood &Cancer, EarlyView.
Stephanie M. Nanos +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
AppliedMathIn the modern era of informatics, where data are very important, efficient management of data is necessary and critical. Two of the most important data management techniques are searching and data ordering (technically sorting).
Anurag Dutta +3 more
doaj +1 more source
Interactive Image Contents Search Based on High Dimensional Information Theory
IEEE Access, 2019 Content-Based Image Retrieval aims at developing techniques that support effective searching and browsing of large image repositories based on image features. The current Content-Based Image Retrieval suffer from the semantic gap.
Cao Pengfei
doaj +1 more source
Linking Mentoring and Job Search Behavior: A Moderated Mediation Model
SAGE Open, 2021 The present research aims to explore the impact of mentoring relationship on college graduates’ job search behavior among Chinese undergraduate students by examining the mediator of job search intention and the moderator of job search self-efficacy.
Ruirui Lian +6 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source