Results 81 to 90 of about 558,831 (256)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Students are Confident Using Federated Search Tools as much as Single Databases
Evidence Based Library and Information Practice, 2011 Objective – To measure students’ perceptions of the ease-of-use and efficacy of a federated search tool versus a single multidisciplinary database. Design – An evaluation worksheet, employing a combination of quantitative and qualitative questions.
Deena Yanofsky
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Applications of GODAE Ocean Current Forecasts to Search and Rescue and Ship Routing [PDF]
Oceanography, 2009 As GODAE ocean forecast systems progress, their contributions toward improving the safety and efficiency of operations at sea will increase. In this article, we review present uses of GODAE ocean forecast systems for various safety applications at sea ...
Fraser J.M. Davidson +10 more
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Protein structural similarity search by Ramachandran codes
BMC Bioinformatics, 2007 Background Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search.
Chang Chih-Hung +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Content-Based Search Tools for Large Sets of Print and Manuscript Music
Transactions of the International Society for Music Information RetrievalWe describe the experiences made at the Bavarian State Library with implementing content-based music search for a subset of collections held at a major research library.
Jürgen Diet, Janosch Umbreit
doaj +1 more source
Approaches to increase the validity of gene family identification using manual homology search tools. [PDF]
Genetica, 2023 Nestor BJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source