Results 61 to 70 of about 558,831 (256)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Análisis del buscador múltiple Copernic 2001 Pro

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2002
Anàlisi del cercador múltiple Copernic 2001 Pro, eina que transmet una equació de cerca a un conjunt de cercadors de manera simultània, en recupera les referències pertinents i les ordena segons el grau mitjà de rellevància obtingut de cadascun dels ...
Franganillo, Jorge, Figuerola, Teresa Maria   +1 more
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Keyword Research : métodos y herramientas para identificar palabras clave

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2011
Objetivos. Presentar las herramientas llamadas Keyword Research Tools. Se trata de herramientas muy extendidas en los ámbitos del SEO y SEM que ayudan a identificar palabras clave con las cuales posicionar un sitio web. -- Metodología.
Vállez Letrado, Mari
doaj  

PubMed’s Native Interface Remains the Best Tool for Systematic Searching of its Biomedical Citations

Evidence Based Library and Information Practice, 2017
A Review of: Wildgaard, L. E., & Lund, H. (2016). Advancing PubMed? A comparison of third-party PubMed/Medline tools. Library Hi Tech, 34 (4), 669-684.
Ann Glusker
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Keyword Research : mètodes i eines per identificar les paraules clau

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2011
Objectius. Presentar les eines anomenades Keyword Research Tools. Es tracta d'eines molt esteses en l'àmbit del SEO i del SEM que ajuden a identificar les paraules clau amb les quals posicionar un lloc web. -- Metodologia.
Vállez Letrado, Mari
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Sistemas de búsqueda y acceso al libro digital en la Web

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2011
En los últimos años los sistemas de búsqueda y acceso a los libros digitales han experimentado una gran evolución. En este trabajo se presentan y describen algunos de los más importantes, así como sus herramientas de búsqueda.
Pedraza Jiménez, Rafael
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source