Results 41 to 50 of about 25,195 (291)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Architecture modeling for system collaborative combat based on unified architecture framework (UAF) [PDF]
Zhihui kongzhi yu fangzhenFacing the continuous improvement of war complexity under the trend of system-of-systems confrontation,this paper introduces MBSE to the modeling design of complex system-of-systems combat. Adopting Unified Architecture Framework, a modeling method based
LI Delin, ZHANG Yuchen, WANG Jun, LIU Naihao
doaj +1 more source
Algorithm Engineering for Sorting and Searching, and All That (Invited Talk)
, 2020 We look at several proposals to engineer the set of fundamental searching and sorting algorithms. Aspects are improving locality of disk access and cache access, the efficiency tuning by reducing the number of branch mispredictions, and reducing at ...
Edelkamp, Stefan
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
The Folklore of Sorting Algorithms [PDF]
, 2009 The objective of this paper is to review the folklore knowledge seen in research work devoted on synthesis, optimization, and effectiveness of various sorting algorithms.
Khamitka, Santosh +3 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Searching, Sorting, and Cake Cutting in Rounds [PDF]
, 2023 We study searching and sorting in rounds motivated by a fair division question: given a cake cutting problem with $n$ players, compute a fair allocation in at most $k$ rounds of interaction with the players.
Brânzei, Simina +2 more
core +1 more source
AppliedMathIn the modern era of informatics, where data are very important, efficient management of data is necessary and critical. Two of the most important data management techniques are searching and data ordering (technically sorting).
Anurag Dutta +3 more
doaj +1 more source