Results 51 to 60 of about 25,195 (291)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

COMPARING SEARCHING AND SORTING ALGORITHMS EFFICIENCY IN IMPLEMENTING COMPUTATIONAL EXPERIMENT IN PROGRAMMING ENVIRONMENT

Ìнформаційні технології в освіті, 2011
This article considers different aspects which allow defining correctness of choosing sorting algorithms. Also some algorithms, needed for computational experiments for certain class of programs, are compared.
R. Sagan
doaj  

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

Scientific Reports, 2022
Mosquito saliva facilitates blood feeding through the anti-haemostatic, anti-inflammatory and immunomodulatory properties of its proteins. However, the potential contribution of non-coding RNAs to host manipulation is still poorly understood. We analysed
Carmine Fiorillo, Pei-Shi Yen, Alessio Colantoni, Marina Mariconti, Nayara Azevedo, Fabrizio Lombardo, Anna-Bella Failloux, Bruno Arcà   +7 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A New Hybrid Metaheuristic Algorithm for Multiobjective Optimization Problems

International Journal of Computational Intelligence Systems, 2020
The elitist nondominated sorting genetic algorithm (NSGA-II) is hybridized with the sine-cosine algorithm (SCA) in this paper to solve multiobjective optimization problems.
M.A. Farag, A.A. Mousa, M.A. El-Shorbagy, I.M. El-Desoky, A.A. Mousa, I.M. El-Desoky   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Computer Aided Learning Hashing, Searching, dan Sorting pada Mata Kuliah Sistem Berkas [PDF]

, 2002
Pembuatan tugas akhir ini berkaitan dengan pembuatan aplikasi sistem CAL, dengan topik materi searching, hashing, dan sorting. Permasalahan searching, hashing, dan sorting merupakan salah satu topik dari mata kuliah sistem berkas yang diajarkan di ...
Sieto, Leonardo
core   +2 more sources

CREATION SOFTWARE COMPLEX FOR LECTURE MATERIALS CREATION AND SUGGESTS

Ìнформаційні технології в освіті, 2010
The article analyzes weaknesses of existing tools for lecture materials creation and suggests ways to address them. New modular complex architecture is proposed, which will support different types of lecture materials, templates, interactive elements ...
V. V. Polinovskyi, V. A. Gerasymenko
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

SOFTWARE COMPLEX FOR CREATION AND ACCUMULATION OF MODERN LEARNING MATERIALS

Ìнформаційні технології в освіті, 2010
The article analyzes weaknesses of existing tools for lecture materials creation and suggests new complex with modular architecture, which supports different types of lecture materials, templates, interactive elements, includes lecture material database ...
V. V. Polinovskyi, V. A. Gerasymenko
doaj