Results 51 to 60 of about 178,130 (288)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Sorting algorithms [PDF]

, 2011
Pri obrovských objemech dat, které se behem výrobních procesu zpracovávají, je snadná orientace a hledání v nich zcela zásadní. Správné a rychlé trídení dat je jednou z nejduležitejších cinností pri jejich zpracování.
Schwarz, Jakub
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

The Search-o-Sort Theory

AppliedMath
In the modern era of informatics, where data are very important, efficient management of data is necessary and critical. Two of the most important data management techniques are searching and data ordering (technically sorting).
Anurag Dutta, Sanjeev Kumar, Deepkiran Munjal, Pijush Kanti Kumar   +3 more
doaj   +1 more source

MicroRNAs and other small RNAs in Aedes aegypti saliva and salivary glands following chikungunya virus infection

Scientific Reports, 2022
Mosquito saliva facilitates blood feeding through the anti-haemostatic, anti-inflammatory and immunomodulatory properties of its proteins. However, the potential contribution of non-coding RNAs to host manipulation is still poorly understood. We analysed
Carmine Fiorillo, Pei-Shi Yen, Alessio Colantoni, Marina Mariconti, Nayara Azevedo, Fabrizio Lombardo, Anna-Bella Failloux, Bruno Arcà   +7 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

COMPARING SEARCHING AND SORTING ALGORITHMS EFFICIENCY IN IMPLEMENTING COMPUTATIONAL EXPERIMENT IN PROGRAMMING ENVIRONMENT

Ìнформаційні технології в освіті, 2011
This article considers different aspects which allow defining correctness of choosing sorting algorithms. Also some algorithms, needed for computational experiments for certain class of programs, are compared.
R. Sagan
doaj  

A New Hybrid Metaheuristic Algorithm for Multiobjective Optimization Problems

International Journal of Computational Intelligence Systems, 2020
The elitist nondominated sorting genetic algorithm (NSGA-II) is hybridized with the sine-cosine algorithm (SCA) in this paper to solve multiobjective optimization problems.
M.A. Farag, A.A. Mousa, M.A. El-Shorbagy, I.M. El-Desoky, A.A. Mousa, I.M. El-Desoky   +5 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source