Results 71 to 80 of about 23,812 (301)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Improved sorting networks with O(log n) depth [PDF]

The sorting network described by Ajtai, KomlOs and Szemeredi was the first to achieve a depth of O(Iog n). The networks introduced here are simplifications and improvements based strongly on their work.
Paterson, Michael S.
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Textual and chemical information processing: different domains but similar algorithms

Information Research: An International Electronic Journal, 2000
This paper discusses the extent to which algorithms developed for the processing of textual databases are also applicable to the processing of chemical structure databases, and vice versa.
Peter Willett
doaj  

iFLEX: A Fully Open-Source, High-Density Field-Programmable Gate Array (FPGA)-Based Hardware Co-Processor for Vector Similarity Searching

IEEE Access, 2019
Vector similarity searching consists of comparing a query vector against a high volume of entries in a reference data set, according to a chosen similarity metric such as the L1-norm, L2-norm, or Hamming distance.
Ludovico Minati, Vardan Movsisyan, Matthew Mccormick, Khachatur Gyozalyan, Tigran Papazyan, Hrach Makaryan, Stefano Aldrigo, Taron Harutyunyan, Hayk Ghaltaghchyan, Chris Mccormick, Mick Fandrich   +10 more
doaj   +1 more source

Combined Heat and Power Economic Emission Dispatch Using Hybrid NSGA II-MOPSO Algorithm Incorporating an Effective Constraint Handling Mechanism

IEEE Access, 2020
This research work proposes a synergistic hybrid metaheuristic algorithm a merger of Nondominated Sorting Genetic Algorithm II and Multiobjective Particle Swarm Optimization algorithm for solving the highly complicated combined heat and power economic ...
Arunachalam Sundaram
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Unified Hardware-Software Complex Of Modern Learning Materials Creation And Collection Automatization

Ìнформаційні технології в освіті, 2009
The article analyzes modern learning materials (MLM) creation problems and the existing tools for such materials creation, their weaknesses and suggests ways to address them.
V. V. Polinovskyi, V. A. Gerasymenko
doaj  

Printed Arabic Words Recognition Using Genetic Algorithm

الأستاذ, 2016
The automatic recognition of  text on scanned images has enabled many application such as searching for words in large volumes of  documents, automatic sorting of postal mail, and convenient editing of previously printed documents.
Assist.Teach.Rasha H.Ali
doaj   +1 more source