Results 111 to 120 of about 3,641 (196)

Lingering challenges in malaria elimination efforts in sub‐Saharan Africa: Insights and potential solutions

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Introduction Between 2000 and 2015, significant gains were recorded in reducing the global burden of malaria due to enhanced global collaboration and increased funding. However, progress has stagnated post‐2015, and the COVID‐19 pandemic seems to have reversed some of these gains, necessitating a critical reevaluation of interventions.
Lukman Lawal, Ahmad Oyindamola Buhari, Tawakalitu Abdulateef Jaji, Abdulrahman Salaudeen Alatare, Abdulmalik Opeyemi Adeyemo, Aishat Oluwakemi Olumoh, Yusuff Adesoji Yusuff, Gabriel Osborn, Abdulazeez Biodun Mogaji, Bello Hussein Adoto, Nafisa Gbemisola Ibrahim, Waliyullahi Oluwafemi Saliu, Toufik Abdul‐Rahman   +12 more
wiley   +1 more source

Co-morbidity of malnutrition with falciparum malaria parasitaemia among children under the aged 6–59 months in Somalia: a geostatistical analysis [PDF]

, 2018
Background Malnutrition and malaria are both significant causes of morbidity and mortality in African children. However, the extent of their spatial comorbidity remains unexplored and an understanding of their spatial correlation structure would inform ...
Berkley, James, Kandala, Ngianga-Bakwin, Kinyoki, Damaris, Moloney, Grainne, Noor, Abdisalan, Odundo, Elijah, Snow, Robert, Uthman, Olalekan   +7 more
core   +3 more sources

Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.
Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding, Richard M. Hoglund, Joel Tarning   +2 more
wiley   +1 more source

A Public Health Paradox: The Women Most Vulnerable to Malaria Are the Least Protected [PDF]

, 2016
Raquel Gonzalez and colleagues highlight an urgent need to evaluate antimalarials that can be safely administered to HIV-infected pregnant women on antiretroviral treatment and cotrimoxazole ...
González, Raquel, Jagoe, George, Menéndez, Clara, Sevene, Esperança Júlia Pires, Slutsker, Laurence   +4 more
core   +3 more sources

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery

Malaria Journal
Background The World Health Organization recommends perennial malaria chemoprevention (PMC), generally using sulfadoxine-pyrimethamine (SP) to children at high risk of severe Plasmodium falciparum malaria.
Swapnoleena Sen, David Schellenberg, Melissa A. Penny   +2 more
doaj   +1 more source

Malaria Prevention Strategies in South Sudan

South Sudan Medical Journal, 2020
The whole of South Sudan is endemic for malaria, with high transmission in the country throughout the year. Malaria is the leading cause of illness and death in children under five years. In 2019, the malaria incidence (all ages) was estimated at 246 per
Harriet Akello Pasquale
doaj  

Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. [PDF]

, 2017
Studies designed to determine the effects of mass administration of azithromycin on trachoma have suggested that mass azithromycin distributions may also reduce the prevalence of malaria. These studies have typically examined the impact of a small number
Amza, Abdou, Bailey, Robin L, Cotter, Chris, Cotter, Sun Y, Gaynor, Bruce D, Kadri, Boubacar, Lietman, Thomas M, Nassirou, Baido, O'Brien, Kieran S, Porco, Travis C, Rosenthal, Philip J, Stoller, Nicole E, West, Sheila K, Zhou, Zhaoxia   +13 more
core   +2 more sources

Beninese Plant Extracts with Antiplasmodial Activity Select New Allele Variants Msp1 and Msp2 in Plasmodium falciparum

Journal of Parasitology Research, Volume 2024, Issue 1, 2024.
Background. Natural medicinal products are commonly used as a remedy against malaria infections in African populations and have become a major source of information for the screening of new and more effective antiplasmodial molecules. Therefore, in vitro studies are needed to validate the efficacy of these medicinal products and to explore the ...
Hamirath O. Lagnika, Adandé A. Medjigbodo, Oswald Y. Djihinto, Helga M. Saïzonou, Wassiyath A. Mousse, Romaric Akoton, Laurette Djossou, Doris N. Vodounkpe, Latifou Lagnika, Luc S. Djogbénou, Bernard Marchand   +10 more
wiley   +1 more source