Results 91 to 100 of about 686,514 (182)

Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness

Malaria Journal, 2021
Background Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period.
Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Seydou Bienvenu Ouattara, Franck A. Yao, Thierry Lefèvre, Issaka Zongo, Frederic Nikièma, Yves Daniel Compaoré, Halidou Tinto, Daniel Chandramohan, Brian Greenwood, Adrien M. G. Belem, Anna Cohuet, Jean Bosco Ouédraogo   +13 more
doaj   +1 more source

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster‐Randomised Trial

Maternal &Child Nutrition, Volume 21, Issue 4, October 2025.
Globally nearly 40% of children under 5 years old are anaemic, which affects their ability to grow and develop. A cluster randomised trial was conducted in 60 communities in Southern Mali to evaluate the added impact of home fortification with micronutrient powders, delivered alongside seasonal malaria chemoprevention, on anaemia, malaria infection ...
Niélé H. Diarra, Yahia Dicko, Natalie Roschnik, Modibo Bamadio, Michael Boivin, Yvonne Griffiths, Rebecca Jones, Sham Lal, Helen Moestue, Hamidou Niangaly, Lauren Pisani, Renion Saye, Kalifa Sidibe, Karla Smuts, Nia‐An Philippe Thera, Josselin Thuilliez, Hans Verhoef, Moussa Sacko, Siân E. Clarke   +18 more
wiley   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, Volume 89, Issue 5, Page 384-397, September 2025.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trial. [PDF]

, 2008
BACKGROUND: Malaria and anaemia are the leading causes of morbidity and mortality in children in sub-Saharan Africa. We have investigated the effect of intermittent preventive treatment with sulphadoxine-pyrimethamine or artesunate plus amodiaquine on ...
Kweku Margaret, Liu Dongmei, Adjuik, Martin, Daniel Chandramohan, Greenwood Brian, Margaret Kweku, Binka Fred, Fred Binka, Binka, Fred, Chandramohan, Daniel, Mahmood Seidu, Liu, Dongmei, Dongmei Liu, Seidu, Mahmood, Martin Adjuik, Greenwood, Brian, Brian Greenwood, Kweku, Margaret, Seidu Mahmood, Adjuik Martin, Chandramohan Daniel   +20 more
core   +1 more source

The Evolving Landscape of Malaria Prevention Strategies: A Review of Recent Developments

Pathogens
Malaria continues to impose a devastating disease burden globally despite control efforts spanning decades. Its elimination has been hindered by parasite and vector complexity and emerging drug and insecticide resistance, along with unremitting barriers ...
Yathavi Charavanamuttu, Akosua Agyeman Wamba, Andrew W. Taylor-Robinson, Temi Lampejo   +3 more
doaj   +1 more source

Use of population pharmacokinetic‐pharmacodynamic modelling to inform antimalarial dose optimization in infants

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 968-980, April 2025.
Infants bear a significant malaria burden but are usually excluded from participating in early dose optimization studies that inform dosing regimens of antimalarial therapy. Unlike older children, infants' exclusion from early‐phase trials has resulted in limited evidence to guide accurate dosing of antimalarial treatment for uncomplicated malaria or ...
Clifford G. Banda, Joel Tarning, Karen I. Barnes   +2 more
wiley   +1 more source

A simple method for defining malaria seasonality. [PDF]

, 2009
BACKGROUND: There is currently no standard way of defining malaria seasonality, resulting in a wide range of definitions reported in the literature. Malaria cases show seasonal peaks in most endemic settings, and the choice and timing for optimal malaria
Roca-Feltrer, Arantxa, Schellenberg, Joanna RM Armstrong, Carneiro, Ilona, Smith, Lucy, Arantxa Roca-Feltrer, Lucy Smith, Joanna Schellenberg, Ilona Carneiro   +7 more
core   +1 more source

Pharmacokinetics of a Novel Piperaquine Dispersible Granules Formulation Under Fasting and Various Fed Conditions Versus Piperaquine Tablets When Fasted in Healthy Tanzanian Adults: A Randomized, Phase I Study

Clinical and Translational Science, Volume 18, Issue 2, February 2025.
ABSTRACT Piperaquine tetraphosphate (PQP), a long‐acting antimalarial, is being considered in a combination for chemoprevention. Dihydroartemisinin‐piperaquine tablets (hard and dispersible) approved for the treatment of acute uncomplicated malaria should be administered in a fasted state, as PQP bioavailability increases with food.
Florence A. Milando, Said Jongo, Salim Abdulla, Gloria Nyaulingo, Anneth‐Mwasi Tumbo, Sarah Mswata, Juliether Tiago, Beatus S. Bongole, Ashura Mirambo, Kamaka Kassimu, Hussein Mbarak, Mohammed A. Rashid, Ali Hamad, Michael Mihayo, Tunu Ndanzi, Omary Zuberi, Naima Saadia, Mariam Somboka, Mariam Yamba‐Yamba, Theresia Ngonyani, Amina Nditi, Margaret Msuya, Bakari Mwalimu, Hajirani M. Msuya, Khamis Awadh, Ali Ali, Anne Claire Marrast, Denis Gossen, Alice Neequaye, Myriam El‐Gaaloul, Hanu Ramachandruni, Isabelle Borghini‐Fuhrer   +31 more
wiley   +1 more source

Effect of adding azithromycin to the antimalarials used for seasonal malaria chemoprevention on the nutritional status of African children. [PDF]

, 2020
OBJECTIVES: Mass administration of azithromycin has reduced mortality in children in sub-Saharan Africa but its mode of action is not well characterised.
Issaka Zongo, Amadou Tapily, Georgia R. Gore‐Langton, Tapily, Amadou, Jean Bosco Ouedraogo, Daniel Chandramohan, Matthew Cairns, Frederic Nikiema, Alassane Dicko, Barry, Amadou, Halidou Tinto, Diarra, Modibo, Modibo Diarra, Yerbanga, R Serge, Irene Kuepfer, Compaoré, Yves Daniel, Rosemonde M. Guissou, Dicko, Alassane, Greenwood, Brian, Brian Greenwood, Gore-Langton, Georgia R, Ismail Thera, Cairns, Matthew, Yves Daniel Compaoré, de Wit, Mariken M, Samba Coumare, Coumare, Samba, Mariken M. de Wit, Zongo, Issaka, Tinto, Halidou, Nikiema, Frederic, Thera, Ismail, R. Serge Yerbanga, Sagara, Issaka, Kuepfer, Irene, Chandramohan, Daniel, Ouedraogo, Jean Bosco, Guissou, Rosemonde M, Issaka Sagara, Amadou Barry   +39 more
core   +1 more source

Rethinking a hybrid malaria chemoprevention delivery strategy for children in sub-perennial settings: a modelling study integrating age- and seasonally-targeted delivery

Malaria Journal
Background The World Health Organization recommends perennial malaria chemoprevention (PMC), generally using sulfadoxine-pyrimethamine (SP) to children at high risk of severe Plasmodium falciparum malaria.
Swapnoleena Sen, David Schellenberg, Melissa A. Penny   +2 more
doaj   +1 more source