Results 71 to 80 of about 555,914 (187)

Impact of seasonal malaria chemoprevention on hospital admissions and mortality in children under 5 years of age in Ouelessebougou, Mali

Malaria Journal, 2020
Background Seasonal malaria chemoprevention is widely implemented in Sahel and sub-Sahel countries in Africa. Few studies have assessed the impact of the SMC on hospital admission and death when it is implemented in the health system.
Djibrilla Issiaka, Amadou Barry, Tiangoua Traore, Boubacar Diarra, David Cook, Mohamed Keita, Issaka Sagara, Patrick Duffy, Michal Fried, Alassane Dicko   +9 more
doaj   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Effectiveness of seasonal malaria chemoprevention at scale in west and central Africa: an observational study [PDF]

The Lancet, 2020
Seasonal malaria chemoprevention (SMC) aims to prevent malaria in children during the high malaria transmission season. The Achieving Catalytic Expansion of SMC in the Sahel (ACCESS-SMC) project sought to remove barriers to the scale-up of SMC in seven countries in 2015 and 2016.
Ebenezer Baba, Prudence Hamade, Harriet Kivumbi, Maddy Marasciulo, Kolawole Maxwell, Diego Moroso, Arantxa Roca-Feltrer, Adama Sanogo, Joanna Stenstrom Johansson, James Tibenderana, Rahila Abdoulaye, Patrice Coulibaly, Eric Hubbard, Huja Jah, Eugene Kaman Lama, Lantorina Razafindralambo, Suzanne Van Hulle, George Jagoe, André-Marie Tchouatieu, David Collins, Colin Gilmartin, Gladys Tetteh, Yacine Djibo, Fara Ndiaye, Momodou Kalleh, Balla Kandeh, Bala Audu, Godwin Ntadom, Alice Kiba, Yacouba Savodogo, Kodbesse Boulotigam, Djiddi Ali Sougoudi, Timothee Guilavogui, Moussa Keita, Diakalidia Kone, Hadiza Jackou, Ibrahim Ouba, Emile Ouedraogo, Halimatou Alassana Messan, Fatou Jah, Markieu Janneh Kaira, Mariama Sire Sano, Mamadou Chérif Traore, Nadine Ngarnaye, Aishatu Yinusa Cassandra Elagbaje, Christine Halleux, Corinne Merle, Noha Iessa, Shanthi Pal, Houda Sefiani, Rachida Souleymani, Ibrahim Laminou, Daugla Doumagoum, Hamit Kesseley, Matt Coldiron, Rebecca Grais, Musa Kana, Jean Bosco Ouedraogo, Issaka Zongo, Tony Eloike, Sonny Johnbull Ogboi, Jane Achan, Kalifa Bojang, Serign Ceesay, Alassane Dicko, Abdoulaye Djimde, Issaka Sagara, Abdoulaye Diallo, Jean Louis NdDiaye, Kovana Marcel Loua, Khalid Beshir, Matt Cairns, Yolanda Fernandez, Sham Lal, Raoul Mansukhani, Julian Muwanguzi, Susana Scott, Paul Snell, Colin Sutherland, Rhosyn Tuta, Paul Milligan   +80 more
openaire   +2 more sources

Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger

Malaria Journal, 2021
Background In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity
Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa, Jean Louis Abdourahim Ndiaye   +7 more
doaj   +1 more source

Evaluation of seasonal malaria chemoprevention implementation in the Upper East region of Northern Ghana. [PDF]

Malar J
Ghana adopted the WHO-recommended Seasonal Malaria Chemoprevention (SMC) in 2016 following a pilot study as a vital strategy for malaria control. SMC is the intermittent administration of a preventive and curative dose of anti-malarial medicine (Sulfadoxine-Pyrimetamine + Amodiaquine) during four months of the malaria season.
Ayamba EY, Dzotsi EK, Dormechele W, Ansah NA, Bangre O, Nyuzaghl JA, Abilba SA, Boakye-Boateng SK, Ansah PO.   +8 more
europepmc   +4 more sources

Impact of seasonal malaria chemoprevention timing on clinical malaria incidence dynamics in the Kedougou region, Senegal. [PDF]

PLOS Glob Public Health
Abstract Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine and amodiaquine is recommended by the World Health Organization since 2012 for clinical malaria prevention in children in the Sahelian region of Africa. In Senegal, SMC implementation began in 2013 and is given to children under 10 years old. This study aimed
Kazanga B, Ba EH, Legendre E, Cissoko M, Fleury L, Bérard L, Diop A, Sokhna C, Danfakha F, Sagara I, Ndiaye JL, Gaudart J, Landier J.   +12 more
europepmc   +5 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Cost-effectiveness of seasonal malaria chemoprevention in upper west region of Ghana [PDF]

Malaria Journal, 2016
In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region.
Nonvignon, Justice, Aryeetey, Genevieve Cecilia, Issah, Shamwill, Ansah, Patrick, Malm, Keziah L., Ofosu, Winfred, Tagoe, Titus, Agyemang, Samuel Agyei, Aikins, Moses   +8 more
openaire   +2 more sources

Seasonal Malaria Chemoprevention in Guinea in 2020: coverage survey results [PDF]

, 2021
In 2020 SMC was implemented in 17 out of 33 prefectures, which include 50% of the population outside the city of Conakry. The COVID-19 pandemic, and the presidential elections in Guinea, could potentially have affected SMC campaigns in 2020, it was therefore important to evaluate coverage of SMC given these challenges and the increased area of ...
Loua, Kovana Marcel, Milligan, Paul
openaire   +1 more source

Age-shifting in malaria incidence as a result of induced immunological deficit : a simulation study [PDF]

, 2015
Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not permanently interrupt transmission.
Hodel, EvaMaria, Kay, Katherine, Hodel, Eva Maria, Smith, Thomas A., Pemberton-Ross, Peter, Smith, Thomas A, Penny, Melissa A.   +6 more
core   +1 more source