Results 61 to 70 of about 686,514 (182)
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source
Review of contextual factors related to seasonal malaria chemoprevention
, 2022 Report considered by the WHO/GMP Guideline Development Group on Malaria Chemoprevention for “Section 4.2.3 Seasonal malaria chemoprevention (SMC)” of the WHO Guidelines for malaria, 3 June 2022.
Bhattarai A +4 more
openaire +2 more sources
Cost-effectiveness of seasonal malaria chemoprevention in upper west region of Ghana [PDF]
Malaria Journal, 2016 In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region.
Nonvignon, Justice +8 more
openaire +2 more sources
Timing of the 5 monthly cycles of seasonal malaria chemoprevention delivery in each village.
, 2019 Timing of the 5 monthly cycles of seasonal malaria chemoprevention delivery in each village.
Colin Sutherland (53387) +12 more
core +1 more source
Acceptability by community health workers in Senegal of combining community case management of malaria and seasonal malaria chemoprevention [PDF]
, 2013 Community case management of malaria (CCMm) and seasonal malaria chemoprevention (SMC) are anti-malarial interventions that can lead to substantial reduction in malaria burden acting in synergy.
Jean L Ndiaye +23 more
core +1 more source
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background and Aims Malaria remains a major global health challenge, with the World Health Organization (WHO) African Region accounting for the overwhelming majority of malaria cases and deaths worldwide. This narrative review examines the contribution of community‐centric malaria prevention approaches to malaria elimination pathways and their
Emmanuel Ifeanyi Obeagu
wiley +1 more source
Malaria Journal, 2023 Abstract Background SMC was adopted in Nigeria in 2014 and by 2021 was being implemented in 18 states, over four months between June and October by 143000 community drug distributors (CDDs) to a target population of 23million children. Further expansion of SMC is planned, extending to 21 states
Nnenna Ogbulafor +16 more
openaire +3 more sources
, 2022 Additional file 1: Figure S1. Heterogeneity of yearly and cycle seasonal malaria chemoprevention effects in the districts of Togo from 2016 to 2020. Deviation of each district from the average is represented for yearly and cycle effects.
Nicolas Voirin (145764) +7 more
core +1 more source
Infectious Diseases of Poverty, 2023 Abstract Background Children under five are the vulnerable population most at risk of being infected with Plasmodium parasites, especially in the Sahel region. Seasonal malaria chemoprevention (SMC) recommended by World Health Organization (WHO), has proven to be a highly effective intervention to prevent malaria.
Ming Xu +10 more
openaire +3 more sources
Malaria Journal, 2021 Background Malaria and malnutrition remain major problems in Sahel countries, especially in young children. The direct effect of malnutrition on malaria remains poorly understood, and may have important implications for malaria control.
Mariken de Wit +18 more
doaj +1 more source