Results 1 to 10 of about 61,380 (160)

Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development

Molecules, 2022
Advancement in novel target detection using improved molecular cancer biology has opened up new avenues for promising anti-cancer drug development. In the past two decades, the mechanism of tumor hypoxia has become more understandable with the discovery ...
Rituparna Ghosh, Priya Samanta, Rupali Sarkar, Souradeep Biswas, Prosenjit Saha, Subhadip Hajra, Arijit Bhowmik   +6 more
doaj   +1 more source

The Target Differences of Anti-Tumorigenesis Potential of Curcumin and its Analogues Against HER-2 Positive and Triple-Negative Breast Cancer Cells [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: The current study aims to evaluate the in vitro cytotoxic and cell migration effects of synthetic curcumin and its analogues on HER2 and nuclear factor kappa B (NFκB) pathways, as well as the in vivo inhibitory effect on cancer growth of ...
Edy Meiyanto, Ulfatul Husnaa, Ria Fajarwati Kastian, Herwandhani Putri, Yonika Arum Larasati, Annisa Khumaira, Dyaningtyas Dewi Putri Pamungkas, Riris Istighfari Jenie, Masashi Kawaichi, Beni Lestari, Takashi Yokoyama, Jun-ya Kato   +11 more
doaj   +1 more source

In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells

Journal of the Egyptian National Cancer Institute, 2023
Background We previously reported that in highly metastatic breast cancer cells, doxorubicin (DOX) at non-toxic concentrations promoted cell migration and invasion.
Nur Dina Amalina, Irfani Aura Salsabila, Ummi Maryam Zulfin, Riris Istighfari Jenie, Edy Meiyanto   +4 more
doaj   +1 more source

Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study

Scientific Reports, 2022
The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its aggressiveness.
Adam Hermawan, Febri Wulandari, Naufa Hanif, Rohmad Yudi Utomo, Riris Istighfari Jenie, Muthi Ikawati, Ahmad Syauqy Tafrihani   +6 more
doaj   +1 more source

Cardamom Essential Oil Extract Suppress the Progression of Triple-Negative Breast Cancer 4T1 Cell Line

Indonesian Biomedical Journal, 2023
BACKGROUND: Cardamom (Amomum cardamom) essential oil (CEO) contains monoterpenes with antioxidant activity and is reported to exhibit anticancer activity against some cancer cell lines.
Ahmad Syauqy Tafrihani, Nisa Ul Hasanah, Dhiya Ulhaq Salsabila, Ratih Kurnia Wardani, Ummi Maryam Zulfin, Muthi' Ikawati, Edy Meiyanto, Riris Istighfari Jenie   +7 more
doaj   +1 more source

In silico validation of potent phytochemical orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 binding

Heliyon, 2021
The present wellbeing worry to the whole world is the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19.
Arijit Bhowmik, Souradeep Biswas, Subhadip Hajra, Prosenjit Saha   +3 more
doaj   +1 more source

Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention [PDF]

, 2014
The isothiocyanate (ITC) sulforaphane (SFN) was shown at low levels (1-5 µM) to promote cell proliferation to 120-143% of the controls in a number of human cell lines, whilst at high levels (10-40 µM) it inhibited such cell proliferation.
A Arlt, A Giudice, A Herman-Antosiewicz, A Lau, A Lister, A Melchini, A Speciale, AA Alfadda, AJ Vargas, AT Dinkova-Kostova, AV Gasper, C Cornelius, C Fimognari, C Fimognari, Changhao Sun, CR Zhao, D Li, D Rand, D Ren, Daotai Nie, DD Zhang, DS Michaud, E Warwick, EJ Calabrese, EJ Calabrese, EJ Calabrese, EJ Calabrese, ER Hahm, F Ekiz, F Galgano, F Zanichelli, GM DeNicola, GR Fenwick, GS Omenn, HK Na, I Misiewicz, I Oehme, IS Santos, J Jakubikova, J Watson, JD Clarke, JD Hayes, JD Watson, JM Cramer, K Pietsch, K Suppipat, KA Moy, KL Cheung, L Gamet-Payrastre, L Kuang, L Ye, LN Barrera, LS Cooley, M McMahon, MB Sporn, MP Mattson, MP Mattson, P Sestili, P Shelton, PE Miller, R Brigelius-Flohe, RF Clayton, RK Thimmulappa, S Homma, SA McNaughton, SJ Jackson, SL Navarro, T Hara, T Nishikawa, T Xu, TG Son, TW Kensler, TW Kensler, V Calabrese, V Rungapamestry, W Hendrickx, Wei Wang, X Ma, X Yu, XJ Wang, Y Ji, Y Li, Y Mitsuishi, Y Shan, Y Zhang, Y Zhang, Y Zhang, Y Zhang, YJ Surh, Yongping Bao, YS Keum, Zhigang Zhou   +91 more
core   +10 more sources

Bioinformatics Analysis Confirms the Target Protein Underlying Mitotic Catastrophe of 4T1 Cells under Combinatorial Treatment of PGV-1 and Galangin

Scientia Pharmaceutica, 2021
Pentagamavunon-1 (PGV-1), a potential chemopreventive agent with a strong cytotoxic effect, modulates prometaphase arrest. Improvement to get higher effectiveness of PGV-1 is a new challenge. A previous study reported that the natural compound, galangin,
Nurul Awali Fauziyah Hasbiyani, Febri Wulandari, Eri Prasetyo Nugroho, Adam Hermawan, Edy Meiyanto   +4 more
doaj   +1 more source

Germline genetic variation in prostate susceptibility does not predict outcomes in the chemoprevention trials PCPT and SELECT [PDF]

, 2020
Background The development of prostate cancer can be influenced by genetic and environmental factors. Numerous germline SNPs influence prostate cancer susceptibility.
Ahmed, M, Cieza-Borrella, C, Eeles, R, Goh, C, Kote-Jarai, Z, PRACTICAL consortium, Saunders, E, Schumacher, FR   +7 more
core   +2 more sources

Hesperetin alleviates doxorubicin-induced migration in 4T1 breast cancer cells

Future Journal of Pharmaceutical Sciences, 2020
Background Hesperetin (Hst), a citrus flavanone, is widely distributed among citrus fruits, including lemons. Hst has been shown to possess bioactivity as an antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotector, and anticancer ...
Erma Yunita, Haruma Anggraini Muflikhasari, Gagas Pradani Nur Ilmawati, Edy Meiyanto, Adam Hermawan   +4 more
doaj   +1 more source