Results 31 to 40 of about 33,930 (226)

Nanotechnology-based cancer chemoprevention in glioblastoma

, 2023
Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on genetic alterations. Glioblastoma rapid progression, drug resistance, and recurrence have been scientifically linked to several factors, including its ...
Gulnara Kapanova, Aima Adylova, Karlygash Raganina, Gulnur Tanbayeva, Zaure Datkhayeva, Kaini Baigonova   +5 more
core   +1 more source

Chemoprevention of metastasis

Oncotarget, 2014
Cancer chemoprevention employs natural, synthetic, or biologic substances to reverse, suppress, or prevent the development of cancer. Initially these agents were developed to reduce cancer risk or retard its development, but were not intended to treat cancer. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is used clinically to prevent polyp
Nancy J, Emenaker, Enrique, Zudaire, Brad, St Croix   +2 more
openaire   +2 more sources

Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin.
Rifki Febriansah, Dewi P.P. Dyaningtyas, Sarmoko, Nunuk Aries Nurulita, Edy Meiyanto, Agung Endro Nugroho   +5 more
doaj   +1 more source

CEP55 Inhibitor: Extensive Computational Approach Defining a New Target of Cell Cycle Machinery Agent [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: Centrosomal protein 55 (CEP55) is a pivotal protein for cytokinesis during cell division. This study aimed to provide a comprehensive information about the CEP55 gene, including its expression pattern in several cancer types, conduct functional ...
Beni Lestari, Rohmad Yudi Utomo
doaj   +1 more source

Inaugural meeting of the malaria policy advisory committee to the WHO : conclusions and recommendations [PDF]

, 2012
The Malaria Policy Advisory Committee to the World Health Organization met for the first time from 31 January to 2 February 2012 in Geneva, Switzerland. This article provides a summary of the discussions, conclusions and recommendations from that meeting,
Abdulla, S, Rietveld, A, Abdulla, Salim, Valecha, N, Ringwald, P, Malik, E, Leke, R, D'Souza, Bianca, Valecha, Neena, Meek, S, Greenwood, Brian, D'Souza, B, Robert D Newman, Cibulskis, Richard, Cibulskis, R, Ringwald, Pascal, Mnzava, Abraham, Greenwood, B, Tanner, M, Mendis, Kamini, Rietveld, Aafje, Alonso, P, d'Acremont, Valerie, White, Nicholas, Graves, Patricia, Slutsker, Larry, Mendis, K, Olemese, Peter, Meek, Sylvia, Bosman, Andrea, Schapira, Allan, Cunningham, J, Newman, Robert, Lines, J, Schapira, A, Malik, Elfatih, Mnzava, A, Cunningham, Jane, Tanner, Marcel, Alonso, Pedro, Lines, Jo, Bosman, A, Marsh, K, WHO Malaria Policy Advisory Committee and Secretariat,, Leke, Rose, Olemese, P, WHO Malaria Policy Advisory Committee and Secretariat, Slutsker, L, Binka, Fred, Graves, P, Binka, F, d'Acremont, V, Marsh, Kevin, Newman, R, Advisory, WHOMP, White, N   +55 more
core   +1 more source

Inhibition of ERBB2-overexpressing Tumors by Recombinant Human Prolidase and Its Enzymatically Inactive Mutant

EBioMedicine, 2015
ERBB2 is an oncogenic receptor tyrosine kinase overexpressed in a subset of human breast cancer and other cancers. We recently found that human prolidase (PEPD), a dipeptidase, is a high affinity ERBB2 ligand and cross-links two ERBB2 monomers.
Lu Yang, Yun Li, Arup Bhattacharya, Yuesheng Zhang   +3 more
doaj   +1 more source

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Denis E. Corpet, Pierre, Fabrice, Pierre, Fabrice H.F., Fabrice Pierre, Corpet, Denis E.   +4 more
core   +1 more source

Antimigratory Evaluation from Curcumin-Derived Synthetic Compounds PGV-1 and CCA-1.1 on HCC1954 and MDA-MB-231 Cells

, 2022
Earlier findings reported the anticancer-mediated activities of curcumin-modified compounds Pentagamavunone-1 (PGV-1) and Chemoprevention Curcumin Analog 1.1 (CCA-1.1) with several mechanisms including cell cycle arrest, reactive oxygen species (ROS ...
Novitasari, Dhania, Jenie, Riris Istighfari, Meiyanto, Edy, Kato, Jun-ya   +3 more
core   +1 more source

PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status [PDF]

Advanced Pharmaceutical Bulletin
Purpose: The HLF and HuH-6 cell lines represent hepatocellular carcinoma (HCC) with different characteristics in chromosome content that may give different drug responses. Here, PGV-1 was intended to challenge the growth-suppressing effect on HLF and HuH-
Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto   +8 more
doaj   +1 more source

Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical and pharmacological properties.Methods: CCA-1.1 was prepared by ...
Rohmad Yudi Utomo, Febri Wulandari, Dhania Novitasari, Beni Lestari, Ratna Asmah Susidarti, Riris Istighfari Jenie, Jun-ya Kato, Sardjiman Sardjiman, Edy Meiyanto   +8 more
doaj   +1 more source