Results 51 to 60 of about 33,930 (226)

Exosome-sheathed porous silica nanoparticle-mediated co-delivery of 3,3′-diindolylmethane and doxorubicin attenuates cancer stem cell-driven EMT in triple negative breast cancer

Journal of Nanobiotechnology
Background Therapeutic management of locally advanced and metastatic triple negative breast cancer (TNBC) is often limited due to resistance to conventional chemotherapy.
Rupali Sarkar, Souradeep Biswas, Rituparna Ghosh, Priya Samanta, Shampa Pakhira, Mrinmoyee Mondal, Yashaswi Dutta Gupta, Suman Bhandary, Prosenjit Saha, Arijit Bhowmik, Subhadip Hajra   +10 more
doaj   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Statistical considerations of chemoprevention clinical trials in prostate cancer

, 1999
The design and analysis of chemoprevention trials in prostate cancer is more complicated than that of an ordinary treatment efficacy trial. The following issues must be taken into account when designing prospective randomized chemoprevention trials: (1 ...
Symposium on Strategies for the Chemoprevention of Prostate Cancer, Collette, Laurence, Sylvester, Richard J.   +2 more
core   +1 more source

Australian clinicians and chemoprevention for women at high familial risk for breast cancer

Hereditary Cancer in Clinical Practice, 2009
Objectives Effective chemoprevention strategies exist for women at high risk for breast cancer, yet uptake is low. Physician recommendation is an important determinant of uptake, but little is known about clinicians' attitudes to chemoprevention. Methods
Keogh Louise A, Hopper John L, Rosenthal Doreen, Phillips Kelly-Anne   +3 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Publisher Correction: Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Xiaodong Xie, Huifang Nie, Yu Zhou, Shu Lian, Hao Mei, Yusheng Lu, Haiyan Dong, Fengqiao Li, Tao Li, Bifei Li, Jie Wang, Min Lin, Chaihung Wang, Jingwei Shao, Yu Gao, Jianming Chen, Fangwei Xie, Lee Jia   +17 more
doaj   +1 more source

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Chemoprevention of Human Cancer:A Reasonable Strategy? [PDF]

, 1999
The field of chemoprevention of cancer in humans is at a teenage level of maturity. There is anticipation and energy, and some promising results have come in, but it’s unclear whether the entire enterprise is worth the effort. Reflecting on the status of
Frank L. Meyskens, Meyskens, Frank L
core   +1 more source

Chemoprevention: Will it work? [PDF]

International Journal of Cancer, 1997
Cancer chemoprevention has been a major area of inquiry in the United States for over a decade. The field originated from the confluence of developments in laboratory carcinogenesis and nutritional epidemiology. Although still owing much to other research disciplines, chemoprevention researchers have developed models and methodologies specific to the ...
openaire   +2 more sources