Results 41 to 50 of about 25,830 (181)

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Chemoprevention of colorectal cancer [PDF]

The International Journal of Biological Markers, 2003
NA
Biasco G., Di Marco M., Pantaleo M. A.
openaire   +3 more sources

Honokiol regulates Acute respiratory distress syndrome (ARDS)‐associated pulmonary fibrosis via the miR‐19a‐3p/POSTN axis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Acute respiratory distress syndrome (ARDS) and subsequent pulmonary fibrosis are associated with high mortality and limited treatment options. Periostin (POSTN) is a profibrotic mediator predicted to be regulated by microRNA‐19a‐3p (miR‐19a‐3p), but the relevance of this axis in ARDS‐associated pulmonary fibrosis remains
Weilun Liu, Hsiaohsuan Wang, Hsuanfu Kuo, Chiahung Yen, Modasang Hua, Chiayuan Chang, Zhiwei Xu, Ifan Liu, Chongchao Hsieh, Chihhsin Hsu, Chiayang Li, Shuchi Wang, Yunghsiang Chen, Menghsuan Cheng, Polen Liu   +14 more
wiley   +1 more source

Management of Surgical Margins in the Excision of Oral Leukoplakia: A Scoping Review

Oral Diseases, EarlyView.
ABSTRACT Objective To map the literature on management of surgical margins for oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Methods Searches were performed in five electronic databases and gray literature. Studies involving patients undergoing any type of surgical excision of OL or PVL were included.
Mateus José Dutra, Isaac Santos Araujo, Vivian Petersen Wagner, Isabel Schausltz Pereira Faustino, Marco Meleti, Nikolaos Nikitakis, Márcio Ajudarte Lopes, Alan Roger Santos‐Silva, Caique Mariano Pedroso   +8 more
wiley   +1 more source

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, Volume 65, Issue 9, Page 1052-1062, September 2026.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source

Chemoprevention: Will it work? [PDF]

International Journal of Cancer, 1997
Cancer chemoprevention has been a major area of inquiry in the United States for over a decade. The field originated from the confluence of developments in laboratory carcinogenesis and nutritional epidemiology. Although still owing much to other research disciplines, chemoprevention researchers have developed models and methodologies specific to the ...
openaire   +2 more sources

Quercetin and Cancer Chemoprevention [PDF]

Evidence-Based Complementary and Alternative Medicine, 2011
Several molecules present in the diet, including flavonoids, can inhibit the growth of cancer cells with an ability to act as “chemopreventers”. Their cancer‐preventive effects have been attributed to various mechanisms, including the induction of cell‐cycle arrest and/or apoptosis as well as the antioxidant functions.
GIBELLINI, Lara, PINTI, Marcello, NASI, Milena, J. P. Montagna, DE BIASI, SARA, ROAT, ERIKA, BERTONCELLI, Linda, E. L. Cooper, COSSARIZZA, Andrea   +8 more
openaire   +4 more sources

The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer [PDF]

Advanced Pharmaceutical Bulletin, 2019
Cancer remains a complex disease with increasing global mortality and morbidity. Numerous theories have been established to understand the biological mechanism underlying cancer.
Edy Meiyanto, Yonika Arum Larasati
doaj   +1 more source

A 5‐Year Retrospective Morbidity Profile of School‐Aged Children at Ho Polyclinic, Volta Region, Ghana: Skin Conditions, Malaria, and Respiratory Illnesses as Leading Causes (2018–2022)

Public Health Challenges, Volume 5, Issue 3, September 2026.
Analysis of 10,428 outpatient consultations among school‐aged children attending Ho Polyclinic, Ghana (2018–2022), showed that three conditions accounted for 77.4% of all morbidity: skin conditions (38.3%), malaria (23.0%), and respiratory conditions (16.1%).
Anthoinette Adesope Ekuban, Frank Baiden
wiley   +1 more source

Orchestrated Cu2+-coordinated tetracycline-porphyrin self-assembly remodels tumor microenvironment for photo-enhanced immuno-chemodynamic therapy

Journal of Nanobiotechnology
Reactive oxygen species (ROS)-based nanodynamic therapy is emerging as a promising approach for tumor treatment, particularly in eliciting immune responses for tumor immunotherapy.
Xianbin Sun, Xinyi Wang, Xudong Li, Ya Wang, Ruofei Xu, Xinyi Shen, Ding Tan, Jingjing Liao, Haijun Chen, Yu Gao, Jianping Zheng   +10 more
doaj   +1 more source