Results 21 to 30 of about 37,862 (221)

Chemoprevention of cancer [PDF]

Carcinogenesis, 2000
In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemopreventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor ...
M B, Sporn, N, Suh
openaire   +2 more sources

PGV-1 Causes Disarrangement of Spindle Microtubule Organization Resulting in Aberrant Mitosis in HLF and HuH6 Cells Associated with Altered MYCN Status [PDF]

Advanced Pharmaceutical Bulletin
Purpose: The HLF and HuH-6 cell lines represent hepatocellular carcinoma (HCC) with different characteristics in chromosome content that may give different drug responses. Here, PGV-1 was intended to challenge the growth-suppressing effect on HLF and HuH-
Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto   +8 more
doaj   +1 more source

Preparation and Cytotoxic Evaluation of PGV-1 Derivative, CCA-1.1, as a New Curcumin Analog with Improved-Physicochemical and Pharmacological Properties [PDF]

Advanced Pharmaceutical Bulletin, 2022
Purpose: This study aimed to challenge the anticancer potency of pentagamavunone-1 (PGV-1) and obtain a new compound (Chemoprevention-Curcumin Analog 1.1, CCA-1.1) withimproved chemical and pharmacological properties.Methods: CCA-1.1 was prepared by ...
Rohmad Yudi Utomo, Febri Wulandari, Dhania Novitasari, Beni Lestari, Ratna Asmah Susidarti, Riris Istighfari Jenie, Jun-ya Kato, Sardjiman Sardjiman, Edy Meiyanto   +8 more
doaj   +1 more source

Understanding low chemoprevention uptake by women at high risk of breast cancer: findings from a qualitative inductive study of women’s risk-reduction experiences

BMC Women's Health, 2021
Background Chemoprevention is one of several methods that have been developed to help high-risk women reduce their risk of breast cancer. Reasons for the low uptake of chemoprevention are poorly understood. This paper seeks a deeper understanding of this
Tasleem J. Padamsee, Megan Hils, Anna Muraveva   +2 more
doaj   +1 more source

Ethanolic Extract of Hedyotis corymbosa L. Inhibits Migration and MMP-9 Activity on Metastatic Breast Cancer Cells [PDF]

, 2018
Many natural products have been widely explored for their pharmacological activities, including anticancer activity. Hedyotis corymbosa L. is known for its anticancer properties toward several cancer cell lines.
Novitasari, Dhania, Handayani, Sri, Dhania Novitasari, Jenie, Riris Istighfari, Riris Istighfari Jenie, Sri Handayani   +5 more
core   +1 more source

Two Active Compounds from Caesalpinia sappan L. in Combination with Cisplatin Synergistically Induce Apoptosis and Cell Cycle Arrest on WiDr Cells [PDF]

Advanced Pharmaceutical Bulletin, 2017
Purpose: The aim of this study is to observe the synergistic effect of two active compounds of secang, brazilin and brazilein, combined with cisplatin on WiDr colon cancer cells. Methods: Cytotoxic activities of brazilin (Bi) and brazilein (Be) in single
Sri Handayani, Ratna Asmah Susidarti, Riris Istighfari Jenie, Edy Meiyanto   +3 more
doaj   +1 more source

Current chemoprevention approaches in Lynch syndrome and Familial adenomatous polyposis: a global clinical practice survey

Frontiers in Oncology, 2023
BackgroundInternational chemoprevention preferences and approaches in Lynch syndrome (LS) and APC-associated polyposis, including Familial adenomatous polyposis (FAP) and attenuated FAP (AFAP) have not been previously explored.AimTo describe current ...
Kathryn A. Mraz, Kathryn A. Mraz, Rachel Hodan, Linda Rodgers-Fouche, Sanjeevani Arora, Francesc Balaguer, Jose G. Guillem, Joanne M. Jeter, Priyanka Kanth, Dan Li, David Liska, Joshua Melson, Kimberly Perez, Charite Ricker, Brian H. Shirts, Eduardo Vilar, Bryson W. Katona, Mev Dominguez-Valentin   +17 more
doaj   +1 more source

Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Journal of Nanobiotechnology, 2019
Background The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge.
Jian Liu, Feiyang Li, Junxia Zheng, Bifei Li, Doudou Zhang, Lee Jia   +5 more
doaj   +1 more source

Malaria chemoprevention and drug resistance: a review of the literature and policy implications

Malaria Journal, 2022
Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-malarial drugs used for chemoprevention is perennially threatened by drug resistance.
Christopher V. Plowe
doaj   +1 more source

Inaugural meeting of the malaria policy advisory committee to the WHO : conclusions and recommendations [PDF]

, 2012
The Malaria Policy Advisory Committee to the World Health Organization met for the first time from 31 January to 2 February 2012 in Geneva, Switzerland. This article provides a summary of the discussions, conclusions and recommendations from that meeting,
Abdulla, Salim, D'Souza, Bianca, Valecha, Neena, Greenwood, Brian, Robert D Newman, Cibulskis, Richard, Ringwald, Pascal, Mnzava, Abraham, Mendis, Kamini, Rietveld, Aafje, d'Acremont, Valerie, White, Nicholas, Graves, Patricia, Slutsker, Larry, Olemese, Peter, Meek, Sylvia, Bosman, Andrea, Schapira, Allan, Newman, Robert, Malik, Elfatih, Cunningham, Jane, Tanner, Marcel, Alonso, Pedro, Lines, Jo, WHO Malaria Policy Advisory Committee and Secretariat,, Leke, Rose, WHO Malaria Policy Advisory Committee and Secretariat, Binka, Fred, Marsh, Kevin   +28 more
core   +1 more source