Results 21 to 30 of about 33,930 (226)

Identification of potential targets of the curcumin analog CCA-1.1 for glioblastoma treatment : integrated computational analysis and in vitro study

Scientific Reports, 2022
The treatment of glioblastoma multiforme (GBM) is challenging owing to its localization in the brain, the limited capacity of brain cells to repair, resistance to conventional therapy, and its aggressiveness.
Adam Hermawan, Febri Wulandari, Naufa Hanif, Rohmad Yudi Utomo, Riris Istighfari Jenie, Muthi Ikawati, Ahmad Syauqy Tafrihani   +6 more
doaj   +1 more source

Cardamom Essential Oil Extract Suppress the Progression of Triple-Negative Breast Cancer 4T1 Cell Line

Indonesian Biomedical Journal, 2023
BACKGROUND: Cardamom (Amomum cardamom) essential oil (CEO) contains monoterpenes with antioxidant activity and is reported to exhibit anticancer activity against some cancer cell lines.
Ahmad Syauqy Tafrihani, Nisa Ul Hasanah, Dhiya Ulhaq Salsabila, Ratih Kurnia Wardani, Ummi Maryam Zulfin, Muthi' Ikawati, Edy Meiyanto, Riris Istighfari Jenie   +7 more
doaj   +1 more source

Bioinformatics Analysis Confirms the Target Protein Underlying Mitotic Catastrophe of 4T1 Cells under Combinatorial Treatment of PGV-1 and Galangin

Scientia Pharmaceutica, 2021
Pentagamavunon-1 (PGV-1), a potential chemopreventive agent with a strong cytotoxic effect, modulates prometaphase arrest. Improvement to get higher effectiveness of PGV-1 is a new challenge. A previous study reported that the natural compound, galangin,
Nurul Awali Fauziyah Hasbiyani, Febri Wulandari, Eri Prasetyo Nugroho, Adam Hermawan, Edy Meiyanto   +4 more
doaj   +1 more source

In silico validation of potent phytochemical orientin as inhibitor of SARS-CoV-2 spike and host cell receptor GRP78 binding

Heliyon, 2021
The present wellbeing worry to the whole world is the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also called COVID-19.
Arijit Bhowmik, Souradeep Biswas, Subhadip Hajra, Prosenjit Saha   +3 more
doaj   +1 more source

Hesperetin alleviates doxorubicin-induced migration in 4T1 breast cancer cells

Future Journal of Pharmaceutical Sciences, 2020
Background Hesperetin (Hst), a citrus flavanone, is widely distributed among citrus fruits, including lemons. Hst has been shown to possess bioactivity as an antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotector, and anticancer ...
Erma Yunita, Haruma Anggraini Muflikhasari, Gagas Pradani Nur Ilmawati, Edy Meiyanto, Adam Hermawan   +4 more
doaj   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

A smart dual-drug nanosystem based on co-assembly of plant and food-derived natural products for synergistic HCC immunotherapy

Acta Pharmaceutica Sinica B, 2021
Nanotechnology has emerged as an ideal approach for achieving the efficient chemo agent delivery. However, the potential toxicity and unclear internal metabolism of most nano-carriers was still a major obstacle for the clinical application.
Bingchen Zhang, Jiali Jiang, Pengyu Wu, Junjie Zou, Jingqing Le, Juanfang Lin, Chao Li, Bangyue Luo, Yongjie Zhang, Rui Huang, Jingwei Shao   +10 more
doaj   +1 more source

Research progress and application of the CRISPR/Cas9 gene-editing technology based on hepatocellular carcinoma

Asian Journal of Pharmaceutical Sciences, 2023
Hepatocellular carcinoma (HCC) is now a common cause of cancer death, with no obvious change in patient survival over the past few years. Although the traditional therapeutic modalities for HCC patients mainly involved in surgery, chemotherapy, and ...
Shijing Yu, Ruirui Zhao, Bingchen Zhang, Chunmei Lai, Linyan Li, Jiangwen Shen, Xiarong Tan, Jingwei Shao   +7 more
doaj   +1 more source

Citrus Flavonoids from Citrus reticulata Peels Potentially Target an Autophagy Modulator, MAP1LC3A, in Breast Cancer

, 2021
Citrus flavonoids have been known for their vast biological activities including chemoprevention activities. However, the organic solvent extraction system limits its potential utilization.
Kumara, Dennaya, Angelina, Dhella, Ikawati, Muthi, Anggoro, Bayu   +3 more
core   +1 more source

Chemoprevention of cancer [PDF]

Carcinogenesis, 2000
In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemopreventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor ...
M B, Sporn, N, Suh
openaire   +2 more sources