CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding +2 more
wiley +1 more source
Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung +4 more
wiley +1 more source
Is it time for Africa to adopt primaquine in the era of malaria control and elimination?
Tropical Medicine and Health, 2022 Keypoints Sub-Saharan Africa contributes about 95% of global malaria cases and related deaths. Despite safety concerns adoption of SLD primaquine is needed to further reduce malaria transmission, an essential prerequisite for the elimination of the ...
Richard O. Mwaiswelo +3 more
doaj +1 more source
A Public Health Paradox: The Women Most Vulnerable to Malaria Are the Least Protected [PDF]
, 2016 Raquel Gonzalez and colleagues highlight an urgent need to evaluate antimalarials that can be safely administered to HIV-infected pregnant women on antiretroviral treatment and cotrimoxazole ...
González, Raquel +4 more
core +3 more sources
Risk of Plasmodium falciparum infection in south-west Burkina Faso: potential impact of expanding eligibility for seasonal malaria chemoprevention [PDF]
, 2022 Jean Baptiste Yaro +16 more
openalex +1 more source
Correction: Sub-National Targeting of Seasonal Malaria Chemoprevention in the Sahelian Countries of the Nouakchott Initiative [PDF]
PLOS ONE, 2015 No abstract available.
Abdisalan Mohamed Noor +5 more
openaire +3 more sources
Clinical and Translational Science, Volume 17, Issue 4, April 2024.Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle +9 more
wiley +1 more source
Malaria Prevention Strategies in South Sudan
South Sudan Medical Journal, 2020 The whole of South Sudan is endemic for malaria, with high transmission in the country throughout the year. Malaria is the leading cause of illness and death in children under five years. In 2019, the malaria incidence (all ages) was estimated at 246 per
Harriet Akello Pasquale
doaj
Large-scale delivery of seasonal malaria chemoprevention to children under 10 in Senegal: an economic analysis. [PDF]
Seasonal Malaria Chemoprevention (SMC) is recommended for children under 5 in the Sahel and sub-Sahel. The burden in older children may justify extending the age range, as has been done effectively in Senegal.
Cissé, Badara +9 more
core +1 more source
Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. [PDF]
, 2017 BACKGROUND: People living in malaria endemic areas acquire protection from severe malaria quickly, but protection from clinical disease and control of parasitaemia is acquired only after many years of repeated infections.
Arinaitwe, Emmanuel +11 more
core +1 more source