Results 131 to 140 of about 8,311 (256)

Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. [PDF]

, 2017
BACKGROUND: People living in malaria endemic areas acquire protection from severe malaria quickly, but protection from clinical disease and control of parasitaemia is acquired only after many years of repeated infections.
Arinaitwe, Emmanuel, Dorsey, Grant, Drakeley, Chris, Greenhouse, Bryan, Kamya, Moses R, Mayanja-Kizza, Harriet, Nankabirwa, Joaniter I, Rosenthal, Philip J, Ssewanyana, Isaac, Sullivan, Richard, Tetteh, Kevin KA, Yeka, Adoke   +11 more
core   +1 more source

Introducing field digital data collection systems into seasonal malaria chemoprevention campaigns: opportunities for robust evidence development and national e-health strategies [PDF]

, 2022
Kanda Balla, Kezia Malm, Ousman Njie, Aurore Ogouyemi, Perpetua Uhomoibhi, Abena Poku-Awuku, André-Marie Tchouatieu, Rock Aïkpon, Alieu Bah, Olimatou Kolley, Nnenna Ogbulafor, Samuel Oppong, Kofi Adomako, William Houndjo, Huja Jah, Jaya Banerji, Jamilu Nikau, Cyriaque Affoukou, Elijah Egwu, Camille Houtohossou, Suzanne Van Hulle   +20 more
openalex   +1 more source

Lingering challenges in malaria elimination efforts in sub‐Saharan Africa: Insights and potential solutions

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Introduction Between 2000 and 2015, significant gains were recorded in reducing the global burden of malaria due to enhanced global collaboration and increased funding. However, progress has stagnated post‐2015, and the COVID‐19 pandemic seems to have reversed some of these gains, necessitating a critical reevaluation of interventions.
Lukman Lawal, Ahmad Oyindamola Buhari, Tawakalitu Abdulateef Jaji, Abdulrahman Salaudeen Alatare, Abdulmalik Opeyemi Adeyemo, Aishat Oluwakemi Olumoh, Yusuff Adesoji Yusuff, Gabriel Osborn, Abdulazeez Biodun Mogaji, Bello Hussein Adoto, Nafisa Gbemisola Ibrahim, Waliyullahi Oluwafemi Saliu, Toufik Abdul‐Rahman   +12 more
wiley   +1 more source

A Public Health Paradox: The Women Most Vulnerable to Malaria Are the Least Protected [PDF]

, 2016
Raquel Gonzalez and colleagues highlight an urgent need to evaluate antimalarials that can be safely administered to HIV-infected pregnant women on antiretroviral treatment and cotrimoxazole ...
González, Raquel, Jagoe, George, Menéndez, Clara, Sevene, Esperança Júlia Pires, Slutsker, Laurence   +4 more
core   +3 more sources

Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.
Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding, Richard M. Hoglund, Joel Tarning   +2 more
wiley   +1 more source

Large-scale delivery of seasonal malaria chemoprevention to children under 10 in Senegal: an economic analysis. [PDF]

Seasonal Malaria Chemoprevention (SMC) is recommended for children under 5 in the Sahel and sub-Sahel. The burden in older children may justify extending the age range, as has been done effectively in Senegal.
Cissé, Badara, Conteh, Lesong, Gaye, Oumar, Gomis, Jules F, Hadj Ba, El, Milligan, Paul J, Ndiaye, Jean-Louis, Ndiaye, Mouhamed, Pitt, Catherine, Sy, Ousmane   +9 more
core   +1 more source

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Co-morbidity of malnutrition with falciparum malaria parasitaemia among children under the aged 6–59 months in Somalia: a geostatistical analysis [PDF]

, 2018
Background Malnutrition and malaria are both significant causes of morbidity and mortality in African children. However, the extent of their spatial comorbidity remains unexplored and an understanding of their spatial correlation structure would inform ...
Berkley, James, Kandala, Ngianga-Bakwin, Kinyoki, Damaris, Moloney, Grainne, Noor, Abdisalan, Odundo, Elijah, Snow, Robert, Uthman, Olalekan   +7 more
core   +3 more sources

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study. [PDF]

, 2017
BACKGROUND: The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine-pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uganda and eastern Rwanda.
Abeku, Tarekegn A, Bhasin, Amit, Cox, Jonathan, Egwang, Connie, Egwang, Thomas, Lynch, Caroline A, Pearce, Richard, Pota, Hirva, Roper, Cally   +8 more
core   +1 more source