Results 101 to 110 of about 11,085 (277)
Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman +13 morewiley +1 more sourceOral Examination [PDF]
, 2017 The oral cavity is the first component of the digestive tract, which is delimited by the lips anteriorly and the oropharynx posteriorly. The oral cavity functions as a protective barrier and is an essential component for speech and swallowing ...Burgess, Jeff, Eisen, Drore, Lynch, Denis P, Nordlund, James J., Stafford, Gary L, Villa, Alessandro, Wells, Michael J. +6 morecore +1 more sourceITALIAN CANCER FIGURES - REPORT 2015: The burden of rare cancers in Italy = I TUMORI IN ITALIA - RAPPORTO 2015: I tumori rari in Italia [PDF]
, 2016 OBJECTIVES:
This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy.Adamo, Ms, Adorni, A, Alessi, D, Aletta, P, Amendola, V, Amodio, R, Amodio, Rosalba, Andreone, S, Angelin, T, Anghinoni, E, Annulli, Ml, Autelitano, M, Balducci, C, Baracco, M, Baracco, S, Barale, A, Barchielli, A, Battisti, W, Bella, F, Bella, Francesca, Bellatalla, C, Bellini, A, Belluardo, C, Benatti, P, Benedetto, G, Benfatto, L, Bernazza, E, Bianconi, F, Biavati, P, Bidoli, E, Birri, S, Bizzoco, S, Bizzoco, Sabrina, Bonini, A, Borciani, E, Bordini, M, Bovo, E, Bozzani, F, Braghiroli, B, Brosio, F, Brucculeri, Ma, Brunori, V, Bucalo, G, Bucchi, L, Bugliarello, E, Bulatko, A, Busco, S, Busco, Susanna, Busso, P, Buzzoni, C, Buzzoni, C., Buzzoni, Carlotta, Caiazzo, Al, Calabrese, A, Calabretta, L, Caldarella, A, Candela, G, Cannone, G, Canu, L, Caparelli, M, Cappelletti, M, Caprara, L, Carletti, N, Caroli, S, Cascio, Ma, Cascone, G, Casella, C, Casella, C, Cassetti, Tiziana, Castaing, M, Castaing, Marine, Cavalieri d'Oro, L, Cavallo, R, Cecconami, L, Celesia, Mv, Cena, T, Cercato, Mc, Cesaraccio, R, Chiesa, R, Cirilli, C, Cirilli, Claudia, Cocchioni, M, Codazzi, T, Cogno, R, Colamartini, A, Colavolpe, Af, Cometti, I, Contiero, P, Contrino, Ml, Corbinelli, A, Cordaro, C, Corti, M, Costa, A, Costarelli, D, Coviello, V, Crapanzano, G, Crocetti, Emanuele, Cuccaro, F, Curatella, S, Cusimano, R, Cusimano, Rosanna, D'Alessandro, A, D'Alò, D, Dal Cin, A, Dal Maso, L, Dal Maso, Luigino, Davini, C, De Angelis, Roberta, De Dottori, M, De Maria, V, De Santis, E, De Valiere, E, Dei Tos, Ap, Demurtas, G, Devigili, E, Di Dia, Pp, Di Felice, E, di Grazia, L, Di Gregorio, C, Di Norcia, R, Di Prima, A, Dinaro, Y, Distefano, R, Doa, N, Domati, F, Donini, M, Fabiano, S, Facchinelli, G, Faccini, F, Falcini, F, Falk, M, Fanetti, Ac, Fattoruso, S, Fedele, M, Ferrari, F, Ferretti, S, Fidelbo, M, Filiberti, Ra, Filipazzi, L, Fiore, Ar, Forgiarini, O, Frasca, G, Frassoldi, E, Fusco, M, Fusco, M, Fusco, Mario, Gabbi, C, Gada, D, Garrone, E, Gatta, Gemma, Gatti, L, Gennaro, V, Gennaro, Valerio, Gentilini, Ma, Gerevini, C, Germinetti, F, Ghilardi, S, Ghisleni, S, Giacomin, A, Giacomin, Adriano, Giavazzi, L, Gilardi, F, Giorgetti, S, Giorgi Rossi, Paolo, Giubelli, C, Giuliani, O, Giurdanella, Mc, Gola, G, Goldoni, Ca, Goldoni, Ca, Golizia, Mg, Grandi, L, Greco, A, Guarda, L, Guttadauro, A, Guzzinati, S, Iannelli, A, Ieni, A, Intrieri, T, Kaleci, S, Lando, C, Lavecchia, Am, Lazzarato, F, Le Rose, L, Leone, A, Leone, R, Lombardo, C, Lonati, F, Lucchi, S, Macci, L, Macerata, V, Madeddu, A, Maffei, S, Maghini, A, Magnani, C, Magnani, G, Magoni, M, Mallone, Sandra, Mancini, S, Mancuso, P, Mangone, L, Mangone, L, Mangone, Lucia, Manneschi, G, Mannino, R, Mannino, S, Mannino, Salvatore, Marani, E, Mariani, F, Martorana, C, Marzola, L, Maspero, S, Maule, M, Mazzei, A, Mazzoleni, G, Mazzucco, G, Melcarne, A, Merletti, F, Merlo, E, Michiara, M, Migliari, E, Minerba, S, Minicuzzi, A, Mizzi, M, Monetti, D, Morana, G, Moroni, E, Mosso, Ml, Muni, A, Mura, F, Natali, M, Negrino, L, Nemcova, L, Nicita, C, Nocera, V, Paderni, F, Pala, F, Palumbo, M, Panciroli, E, Panico, M, Pannozzo, F, Pascucci, C, Pasolini, A, Pastore, G, Patriarca, S, Pedroni, M, Perrotta, C, Pesce, P, Petrinelli, Am, Petrucci, C, Pezzarossi, A, Pezzuto, L, Piccinni, L, Pierannunzio, Daniela, Piffer, S, Pinon, M, Pinto, A, Pintori, N, Pirino, D, Pironi, V, Ponz de Leon, M, Prandi, R, Prazzoli, R, Puleio, M, Puppo, A, Quarta, F, Quattrocchi, M, Raho, Am, Ramazzotti, V, Rashid, I, Ravaioli, A, Ravazzolo, B, Ravegnani, M, Reggiani-Bonetti, L, Ricci, P, Rizzello, R, Rognoni, M, Rollo, Pc, Romanelli, A, Roncaglia, F, Roncucci, L, Rosano, A, Rossi, F, Rossi, G, Rossi, M, Rossi, Silvia, Rossini, S, Rosso, S, Rudisi, G, Ruggeri, Mg, Russo, Ag, Ruzza, Mr, Sacchettini, C, Sacchetto, L, Sacco, G, Sacerdote, C, Sala, O, Salvi, O, Sampietro, G, Santucci, C, Scheibel, M, Sciacca, S, Sciacchitano, C, Sciacchitano, S, Scuderi, T, Sechi, O, Seghini, P, Senatore, G, Sensi, F, Serraino, D, Sgargi, P, Sini, Gm, Sobrato, I, Solimene, C, Spagnoli, G, Spano, F, Spata, E, Sperduti, I, Spinosa, S, Staiti, R, Stocco, C, Storchi, C, Stracci, F, Sunseri, R, Susini, N, Sutera Sardo, A, Tagliabue, G, Tamburo, L, Tamburrino, S, Taranto, V, Tavilla, Andrea, Terracini, B, Tisano, F, Tittarelli, A, Tognazzo, S, Tognazzo, Sandro, Torrisi, A, Torrisi, A, Traina, A, Trama, Annalisa, Trapani, C, Tschugguel, B, Tumino, R, Tumino, Rosario, Usala, M, Vacirca, S, Valente, N, Valerio, O, Valla, K, Varvarà, M, Vasquez, E, Vassante, B, Vattiato, R, Vercellino, Pc, Vicentini, M, Vicentini, Massimo, Villa, M, Visoli, C, Vitale, F, Vitale, Maria Francesca, Vitale, Mf, Vitali, B, Vitali, Me, Vitarelli, S, Vittadello, F, Zanchi, A, Zanetti, R, Zani, G, Zanier, L, Zappa, M, Zarcone, M, Ziino, Ac, Zorzi, M, Zucchetto, A, Zucchi, A +374 morecore +1 more sourceCinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU
Advanced Science, EarlyView.Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu +22 morewiley +1 more sourceThe Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow
Advanced Science, EarlyView.This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li +7 morewiley +1 more sourcePapillary cystoadenoma lymphomatosum (Warthin-like) of minor salivary glands [PDF]
, 2009 Papillary cystadenoma lymphomatosum is a benign salivary gland tumor most frequently located in the parotid gland (Warthin?s tumor). Its presentation in other major, or in minor, salivary glands is rare. Clinically, it manifests as a slow growing tumor,Aguirre Urízar, José Manuel, Berini Aytés, Leonardo, Gay Escoda, Cosme, Párraga Linares, Laura +3 morecore +2 more sourcesBiodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma
Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps +20 morewiley +1 more sourceLactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian +16 morewiley +1 more sourceCHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation
Advanced Science, EarlyView.By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang +18 morewiley +1 more source
