Results 161 to 170 of about 3,149 (256)

Dynamic surface control algorithm of flexible manipulator driven by position and velocity disturbance factors. [PDF]

Sci Rep
Tang S, Wang Y, Deng H, Nanehkaran YA.
europepmc   +1 more source

Trackable Tolerogenic Macrophages Integrate PD‐L1 and Rapamycin Signaling to Suppress Alloimmune Responses in Transplantation

Advanced Science, EarlyView.
We developed a macrophage‐based therapeutic platform, termed trackable tolerogenic macrophages (TTM), for dual‐function immunomodulation and visualization in vivo. TTM cells were engineered to overexpress PD‐L1, incorporate bioorthogonal cell surface tags, and load rapamycin for sustained release.
Yihui Wang, Yuan Song, Yuji Xie, Junmin Zhang, Jing Liu, Wenyuan Wang, Ying Xu, Wenqian Wu, Wuqi Zhou, Qiaofeng Jin, Jing Wang, Yali Yang, Li Zhang, Tang Gao, Mingxing Xie   +14 more
wiley   +1 more source

Assessing the Impact of Morphological Parameters on the Mechanical Behavior of Synthetic Meshes. A Multivariate Regression Approach. [PDF]

Int J Numer Method Biomed Eng
Civilini V, Aldieri A, Giacalone V, Audenino AL, Terzini M.   +4 more
europepmc   +1 more source

Synergistic Modulation of Ru–O Bond Covalency via Ba/Fe Co‐Doping and Oxygen‐Vacancy Engineering for Efficient Wide‐pH Oxygen Evolution

Advanced Science, EarlyView.
Ba/Fe co‐doping and oxygen vacancy engineering synergistically modulate the Ru–O bond covalency in RuO2, leading to markedly enhanced OER activity across wide‐pH electrolytes. ABSTRACT Developing efficient and stable oxygen evolution reaction (OER) catalysts across a wide‐pH range is critical for practical water electrolysis.
Zongpeng Wang, Ting Jiang, Reem F. Alshehri, Longfei Ding, Salah M. El‐Bahy, Yuanmo Lin, Puyou Ying, Hongxiang Chen, Hanhui Lei, Terence X. Liu, Zhiping Lin   +10 more
wiley   +1 more source

Designing B₁-Selective Pulses by Frequency Modulating in a Second Rotating Frame. [PDF]

Magn Reson Med
Kantesaria S, Torres E, Mustafa MM, Idiyatullin D, Ponticorvo S, Adriany G, Michaeli S, Garwood M.   +7 more
europepmc   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Polymer-Bonded/Bolted Steel Plates Versus UHPFRC Overlay for Controlling Deflection in RC Shallow Beams with Planted Columns-Experimental Insights. [PDF]

Polymers (Basel)
Elsanadedy H, Baatiah A, Abadel A, Abbas H, Almusallam T, Al-Salloum Y.   +5 more
europepmc   +1 more source

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

A new similitude law for testing scaled RC structures. [PDF]

Sci Rep
Park J, Lee SC, Chae Y, Cho JY.
europepmc   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source