Low to moderate-dose off-label use of second-generation antipsychotics seems to be safe in the light of cardiac adverse effects in child psychiatric patients. [PDF]
Kakko K +3 more
europepmc +1 more source
ABSTRACT Purpose Confounding is a key concern in observational studies using healthcare databases. The high‐dimensional propensity score (HDPS) algorithm is an approach for generating and prioritising proxy variables, leveraging all available information in a database to mitigate residual confounding.
Edmund C. L. Cheung +4 more
wiley +1 more source
Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second-Generation Antipsychotics (SGA)-Induced Metabolic Syndrome (MetS). [PDF]
El Rouby N +8 more
europepmc +1 more source
Psychotropic Use Among Classroom Teachers in Espírito Santo: A Cross‐Sectional Study
ABSTRACT Purpose To assess the prevalence of psychotropic use among classroom teachers and to identify associated factors. Methods A cross‐sectional study was conducted between January and February 2024 in Espírito Santo, Brazil. The study included teachers from 20 state schools selected through probabilistic sampling.
Yohan Cancilheri Mazzini +5 more
wiley +1 more source
Longitudinal impact of different treatment sequences of second-generation antipsychotics on metabolic outcomes: a study using targeted maximum likelihood estimation. [PDF]
Feng Y +6 more
europepmc +1 more source
ABSTRACT Background Clozapine initiation often triggers inflammatory responses that can alter metabolism via Cytochrome P450 1A2 (CYP1A2) suppression. Although C‐reactive protein (CRP) is the recommended marker, it may be unavailable in community settings.
Nicoline Bihelek +3 more
wiley +1 more source
Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. [PDF]
He L +6 more
europepmc +1 more source
Evidence-based recommendations for monitoring safety of second-generation antipsychotics in children and youth [PDF]
Tamara Pringsheim +4 more
openalex +1 more source
ABSTRACT The concurrent use of opioids and benzodiazepines (BZDs) has raised safety concerns due to increased risks of respiratory depression and death. To evaluate mortality risks linked to different patterns of co‐prescription, we conducted a retrospective cohort study using data from a private hospital system between 2008 and 2018.
Fang‐Yu Su +3 more
wiley +1 more source
Consumers' and practitioners' perspectives on the antipsychotic induced metabolic syndrome and challenges in metabolic monitoring to patient prescribed second generation antipsychotics in severe mental illness. [PDF]
Poojari PG +10 more
europepmc +1 more source

