Results 71 to 80 of about 524,666 (307)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Imaging through Nonlinear Metalens Using Second Harmonic Generation [PDF]

open access: yesAdvances in Materials, 2018
The abrupt phase change of light at metasurfaces provides high flexibility in wave manipulation without the need for accumulation of propagating phase through dispersive materials.
C. Schlickriede   +6 more
semanticscholar   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone   +8 more
wiley   +1 more source

X waves generated at the second harmonic [PDF]

open access: yesOptics Letters, 2003
The process of optical frequency doubling in the undepleted regime can lead to the generation of an X-wave envelope with group velocity locked to the pump beam. Its parameters and its angular spectrum are directly related to the zeroth- and first-order dispersive features of the nonlinear process.
CONTI, CLAUDIO, Stefano Trillo
openaire   +2 more sources

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran   +13 more
wiley   +1 more source

Second-Harmonic Generation in Mie-Resonant GaAs Nanowires

open access: yesApplied Sciences, 2019
We investigate the enhancement of second-harmonic generation in cylindrical GaAs nanowires. Although these nanostructures confine light in two dimensions, power conversion efficiencies on the order of 10 − 5 with a pump peak intensity
Domenico de Ceglia   +4 more
doaj   +1 more source

Second harmonic generation in metasurfaces with multipole resonant coupling

open access: yesNanophotonics, 2020
We report on the numerical demonstration of enhanced second harmonic generation (SHG) originating from collective resonances in plasmonic nanoparticle arrays.
Han Aoxue   +3 more
doaj   +1 more source

Zero-Order Second Harmonic Generation from AlGaAs-on-Insulator Metasurfaces

open access: yesACS Photonics, 2019
All-dielectric metasurfaces consist of two-dimensional arrangements of nanoresonators and are of paramount importance for shaping polarization, phase, and amplitude of both fundamental and harmonic optical waves. To date, their reported nonlinear optical
G. Marino   +6 more
semanticscholar   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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